Impact of Diabetes Mellitus on the Association of Vascular Disease Before Transplantation With Long-term Transplant and Patient Outcomes After Kidney Transplantation: A Population Cohort Study

Wai H. Lim, David W. Johnson, Carmel M. Hawley, Elaine Pascoe, Germaine Wong

Research output: Contribution to journalArticle

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Abstract

Background Advances in kidney transplantation have led to considerable improvements in short-term transplant and patient outcomes, but there are few data regarding long-term transplant outcomes in patients with vascular comorbid conditions. This study examined the association of vascular disease before transplantation with transplant and patient survival after transplantation and evaluated whether this association was modified by diabetes. Study Design All deceased donor kidney transplant recipients recorded in the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) for 1990 to 2012. Predictor Vascular disease burden. Outcomes All-cause mortality and overall transplant loss. Potential interactions between diabetes and vascular disease for mortality and transplant loss were assessed using 2-way interaction terms. Results Of 7,128 recipients with 58,120 patient-years of follow-up, 854 (12.0%) and 263 (3.7%) had vascular diseases at 1 and 2 or more sites, respectively. Overall survival for recipients without vascular disease 15 years after transplantation was 65% compared with 35% and 22% among recipients with vascular disease at 1 and 2 or more sites, respectively (P < 0.001). Compared with recipients without vascular disease, adjusted HRs for mortality and transplant loss were 1.75 (95% CI, 1.39-2.20; P < 0.001) and 1.61 (95% CI, 1.30-1.99; P < 0.001), respectively, for recipients with 2 or more vascular diseases. Among recipients without diabetes but with 2 or more vascular diseases, adjusted HRs for mortality and transplant loss were 2.10 (95% CI, 1.56-2.82; P < 0.001) and 1.84 (95% CI, 1.39-2.42; P < 0.001), respectively, compared with those without vascular disease. Similar associations were not observed for recipients with diabetes mellitus (P for interaction < 0.001). Limitations Selection bias and unmeasured residual confounders, such as the severity/extent of comorbid conditions likely to be present. Conclusions The impact of vascular disease on long-term outcomes was modified by the presence of diabetes, whereby excess risks for death and transplant loss are more apparent in recipients without diabetes.

Original languageEnglish
Pages (from-to)102-111
Number of pages10
JournalAmerican Journal of Kidney Diseases
Volume71
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

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Vascular Diseases
Kidney Transplantation
Diabetes Mellitus
Cohort Studies
Transplantation
Transplants
Population
Mortality
Survival
Selection Bias
New Zealand
Blood Vessels
Registries
Dialysis
Tissue Donors
Kidney

Cite this

@article{6892d66945084f7a8ed1a59ae7a38d0f,
title = "Impact of Diabetes Mellitus on the Association of Vascular Disease Before Transplantation With Long-term Transplant and Patient Outcomes After Kidney Transplantation: A Population Cohort Study",
abstract = "Background Advances in kidney transplantation have led to considerable improvements in short-term transplant and patient outcomes, but there are few data regarding long-term transplant outcomes in patients with vascular comorbid conditions. This study examined the association of vascular disease before transplantation with transplant and patient survival after transplantation and evaluated whether this association was modified by diabetes. Study Design All deceased donor kidney transplant recipients recorded in the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) for 1990 to 2012. Predictor Vascular disease burden. Outcomes All-cause mortality and overall transplant loss. Potential interactions between diabetes and vascular disease for mortality and transplant loss were assessed using 2-way interaction terms. Results Of 7,128 recipients with 58,120 patient-years of follow-up, 854 (12.0{\%}) and 263 (3.7{\%}) had vascular diseases at 1 and 2 or more sites, respectively. Overall survival for recipients without vascular disease 15 years after transplantation was 65{\%} compared with 35{\%} and 22{\%} among recipients with vascular disease at 1 and 2 or more sites, respectively (P < 0.001). Compared with recipients without vascular disease, adjusted HRs for mortality and transplant loss were 1.75 (95{\%} CI, 1.39-2.20; P < 0.001) and 1.61 (95{\%} CI, 1.30-1.99; P < 0.001), respectively, for recipients with 2 or more vascular diseases. Among recipients without diabetes but with 2 or more vascular diseases, adjusted HRs for mortality and transplant loss were 2.10 (95{\%} CI, 1.56-2.82; P < 0.001) and 1.84 (95{\%} CI, 1.39-2.42; P < 0.001), respectively, compared with those without vascular disease. Similar associations were not observed for recipients with diabetes mellitus (P for interaction < 0.001). Limitations Selection bias and unmeasured residual confounders, such as the severity/extent of comorbid conditions likely to be present. Conclusions The impact of vascular disease on long-term outcomes was modified by the presence of diabetes, whereby excess risks for death and transplant loss are more apparent in recipients without diabetes.",
keywords = "all-cause mortality, cardiovascular comorbidity, diabetes mellitus (DM), end-stage renal disease (ESRD), graft loss, Kidney transplantation, long-term transplant outcomes, transplant recipient, vascular disease",
author = "Lim, {Wai H.} and Johnson, {David W.} and Hawley, {Carmel M.} and Elaine Pascoe and Germaine Wong",
year = "2018",
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language = "English",
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Impact of Diabetes Mellitus on the Association of Vascular Disease Before Transplantation With Long-term Transplant and Patient Outcomes After Kidney Transplantation : A Population Cohort Study. / Lim, Wai H.; Johnson, David W.; Hawley, Carmel M.; Pascoe, Elaine; Wong, Germaine.

In: American Journal of Kidney Diseases, Vol. 71, No. 1, 01.01.2018, p. 102-111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of Diabetes Mellitus on the Association of Vascular Disease Before Transplantation With Long-term Transplant and Patient Outcomes After Kidney Transplantation

T2 - A Population Cohort Study

AU - Lim, Wai H.

AU - Johnson, David W.

AU - Hawley, Carmel M.

AU - Pascoe, Elaine

AU - Wong, Germaine

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background Advances in kidney transplantation have led to considerable improvements in short-term transplant and patient outcomes, but there are few data regarding long-term transplant outcomes in patients with vascular comorbid conditions. This study examined the association of vascular disease before transplantation with transplant and patient survival after transplantation and evaluated whether this association was modified by diabetes. Study Design All deceased donor kidney transplant recipients recorded in the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) for 1990 to 2012. Predictor Vascular disease burden. Outcomes All-cause mortality and overall transplant loss. Potential interactions between diabetes and vascular disease for mortality and transplant loss were assessed using 2-way interaction terms. Results Of 7,128 recipients with 58,120 patient-years of follow-up, 854 (12.0%) and 263 (3.7%) had vascular diseases at 1 and 2 or more sites, respectively. Overall survival for recipients without vascular disease 15 years after transplantation was 65% compared with 35% and 22% among recipients with vascular disease at 1 and 2 or more sites, respectively (P < 0.001). Compared with recipients without vascular disease, adjusted HRs for mortality and transplant loss were 1.75 (95% CI, 1.39-2.20; P < 0.001) and 1.61 (95% CI, 1.30-1.99; P < 0.001), respectively, for recipients with 2 or more vascular diseases. Among recipients without diabetes but with 2 or more vascular diseases, adjusted HRs for mortality and transplant loss were 2.10 (95% CI, 1.56-2.82; P < 0.001) and 1.84 (95% CI, 1.39-2.42; P < 0.001), respectively, compared with those without vascular disease. Similar associations were not observed for recipients with diabetes mellitus (P for interaction < 0.001). Limitations Selection bias and unmeasured residual confounders, such as the severity/extent of comorbid conditions likely to be present. Conclusions The impact of vascular disease on long-term outcomes was modified by the presence of diabetes, whereby excess risks for death and transplant loss are more apparent in recipients without diabetes.

AB - Background Advances in kidney transplantation have led to considerable improvements in short-term transplant and patient outcomes, but there are few data regarding long-term transplant outcomes in patients with vascular comorbid conditions. This study examined the association of vascular disease before transplantation with transplant and patient survival after transplantation and evaluated whether this association was modified by diabetes. Study Design All deceased donor kidney transplant recipients recorded in the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) for 1990 to 2012. Predictor Vascular disease burden. Outcomes All-cause mortality and overall transplant loss. Potential interactions between diabetes and vascular disease for mortality and transplant loss were assessed using 2-way interaction terms. Results Of 7,128 recipients with 58,120 patient-years of follow-up, 854 (12.0%) and 263 (3.7%) had vascular diseases at 1 and 2 or more sites, respectively. Overall survival for recipients without vascular disease 15 years after transplantation was 65% compared with 35% and 22% among recipients with vascular disease at 1 and 2 or more sites, respectively (P < 0.001). Compared with recipients without vascular disease, adjusted HRs for mortality and transplant loss were 1.75 (95% CI, 1.39-2.20; P < 0.001) and 1.61 (95% CI, 1.30-1.99; P < 0.001), respectively, for recipients with 2 or more vascular diseases. Among recipients without diabetes but with 2 or more vascular diseases, adjusted HRs for mortality and transplant loss were 2.10 (95% CI, 1.56-2.82; P < 0.001) and 1.84 (95% CI, 1.39-2.42; P < 0.001), respectively, compared with those without vascular disease. Similar associations were not observed for recipients with diabetes mellitus (P for interaction < 0.001). Limitations Selection bias and unmeasured residual confounders, such as the severity/extent of comorbid conditions likely to be present. Conclusions The impact of vascular disease on long-term outcomes was modified by the presence of diabetes, whereby excess risks for death and transplant loss are more apparent in recipients without diabetes.

KW - all-cause mortality

KW - cardiovascular comorbidity

KW - diabetes mellitus (DM)

KW - end-stage renal disease (ESRD)

KW - graft loss

KW - Kidney transplantation

KW - long-term transplant outcomes

KW - transplant recipient

KW - vascular disease

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U2 - 10.1053/j.ajkd.2017.08.018

DO - 10.1053/j.ajkd.2017.08.018

M3 - Article

VL - 71

SP - 102

EP - 111

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 1

ER -