Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake

Mohammad Jalili-Nik; Khadijeh Mahboobnia; Paul C. Guest; Muhammed Majeed; Khalid Al-Rasadi; Tannaz Jamialahmadi; Amirhossein Sahebkar

doi:10.1007/978-1-0716-1558-4_29

Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake

Mohammad Jalili-Nik
, Khadijeh Mahboobnia
, Paul C. Guest
, Muhammed Majeed
, Khalid Al-Rasadi
, Tannaz Jamialahmadi
, Amirhossein Sahebkar

Research output: Chapter in Book/Conference paper › Chapter › peer-review

3 Citations (Scopus)

Abstract

Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

Original language	English
Title of host publication	Physical Exercise and Natural and Synthetic Products in Health and Disease
Editors	Paul C. Guest
Publisher	Springer
Pages	395-400
Number of pages	6
ISBN (Electronic)	978-1-0716-1558-4
ISBN (Print)	978-1-0716-1557-7
DOIs	https://doi.org/10.1007/978-1-0716-1558-4_29
Publication status	Published - 2022
Externally published	Yes

Publication series

Name	Methods in Molecular Biology
Volume	2343
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/978-1-0716-1558-4_29

Cite this

Jalili-Nik, M., Mahboobnia, K., Guest, P. C., Majeed, M., Al-Rasadi, K., Jamialahmadi, T., & Sahebkar, A. (2022). Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake. In P. C. Guest (Ed.), Physical Exercise and Natural and Synthetic Products in Health and Disease (pp. 395-400). (Methods in Molecular Biology; Vol. 2343). Springer. https://doi.org/10.1007/978-1-0716-1558-4_29

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title = "Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake",

abstract = "Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.",

keywords = "Atherosclerosis, Cholesterol, Curcumin, Hepatocyte, LDL-C uptake",

author = "Mohammad Jalili-Nik and Khadijeh Mahboobnia and Guest, \{Paul C.\} and Muhammed Majeed and Khalid Al-Rasadi and Tannaz Jamialahmadi and Amirhossein Sahebkar",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

doi = "10.1007/978-1-0716-1558-4\_29",

language = "English",

isbn = "978-1-0716-1557-7",

series = "Methods in Molecular Biology",

publisher = "Springer",

pages = "395--400",

editor = "Guest, \{Paul C.\}",

booktitle = "Physical Exercise and Natural and Synthetic Products in Health and Disease",

address = "Netherlands",

}

Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake. / Jalili-Nik, Mohammad; Mahboobnia, Khadijeh; Guest, Paul C. et al.
Physical Exercise and Natural and Synthetic Products in Health and Disease. ed. / Paul C. Guest. Springer, 2022. p. 395-400 (Methods in Molecular Biology; Vol. 2343).

Research output: Chapter in Book/Conference paper › Chapter › peer-review

TY - CHAP

T1 - Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake

AU - Jalili-Nik, Mohammad

AU - Mahboobnia, Khadijeh

AU - Guest, Paul C.

AU - Majeed, Muhammed

AU - Al-Rasadi, Khalid

AU - Jamialahmadi, Tannaz

AU - Sahebkar, Amirhossein

PY - 2022

Y1 - 2022

N2 - Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

AB - Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.

KW - Atherosclerosis

KW - Cholesterol

KW - Curcumin

KW - Hepatocyte

KW - LDL-C uptake

UR - https://www.scopus.com/pages/publications/85114742951

U2 - 10.1007/978-1-0716-1558-4_29

DO - 10.1007/978-1-0716-1558-4_29

M3 - Chapter

C2 - 34473340

AN - SCOPUS:85114742951

SN - 978-1-0716-1557-7

T3 - Methods in Molecular Biology

SP - 395

EP - 400

BT - Physical Exercise and Natural and Synthetic Products in Health and Disease

A2 - Guest, Paul C.

PB - Springer

ER -

Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake

Abstract

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