Impact of air pollution on respiratory microbiome: A narrative review

Tarsila Vieceli, Sofia Tejada, Raquel Martinez-Reviejo, Tomas Pumarola, Jacques Schrenzel, Grant W. Waterer, Jordi Rello

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Background: Respiratory microbiome composition depends on an intricate balance between host characteristics, diet, and environmental factors. Some studies indicate a bidirectional relationship between respiratory microbiota and disease. Air pollution is consistently associated with increased respiratory morbidity and mortality in different populations and across different ages. The aim of this review was to report a summary of the evidence regarding the impact of air pollution on the upper and lower respiratory tract microbiome. Methods: A literature search from interaction between air pollution and respiratory microbiome was performed (2010–2022). Results: Sixteen studies demonstrated changes in microbiome with both environmental and household air pollution. Increasing levels of air pollutants are associated with lower relative abundance of Corynebacterium and increasing levels of pathogen colonization, such as Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae and Pseudomonas aeruginosa and Acinetobacter baumannii, altering the incidence and clinical course of respiratory infections. This ultimately leads to an excess of morbidity and mortality due to antimicrobial resistance. Conclusion: Changes of air pollution on the respiratory microbiome may influence respiratory infections in critical care. Use of probiotics may restore the diversity of baseline microbiome, preventing infections by resistant organisms in the critical care setting. Using protective equipment decreased the effect of air pollutants on increasing potentially pathogenic microorganisms.
Original languageEnglish
Article number103336
JournalIntensive and Critical Care Nursing
Volume74
DOIs
Publication statusPublished - Feb 2023

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