Abstract
BackgroundIn many settings, the benefits of antiretroviral therapy (ART) are reduced by the high early incidence of tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)MethodsWe used tuberculin skin testing and the QuantiFERON-TB Gold In-Tube assay to investigate cellular immune responses to purified protein derivative (PPD) and region of difference 1 (RD1) antigens during the first 24 weeks of ARTResultsTB-IRIS and ART-associated tuberculosis occurred in 15 of 75 (20%) and 11 of 231 (4.8%) participants at risk, respectively. Greater increases in interferon γ (IFN-γ) and skin test responses to PPD were seen at week 24 and 12 in participants with TB-IRIS (P⩽.04), respectively. Raw IFN-γ responses to RD1 antigens and PPD corrected for pre-ART CD4+ T cell counts were higher at all time points in individuals with ART-associated tuberculosis (P
Original language | English |
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Pages (from-to) | 1736-1745 |
Journal | The Journal of infectious diseases |
Volume | 200 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2009 |