Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy

J.H. Elliott; K. Vohith; S. Saramony; C. Savuth; C. Dara; C. Sarim; S. Huffam; R. Oelrichs; P. Sophea; V. Saphonn; J. Kaldor; D.A. Cooper; M.C. Vun; Martyn French

doi:10.1086/644784

Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy

J.H. Elliott, K. Vohith, S. Saramony, C. Savuth, C. Dara, C. Sarim, S. Huffam, R. Oelrichs, P. Sophea, V. Saphonn, J. Kaldor, D.A. Cooper, M.C. Vun, Martyn French

Research output: Contribution to journal › Article

94 Citations (Scopus)

Abstract

BackgroundIn many settings, the benefits of antiretroviral therapy (ART) are reduced by the high early incidence of tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)MethodsWe used tuberculin skin testing and the QuantiFERON-TB Gold In-Tube assay to investigate cellular immune responses to purified protein derivative (PPD) and region of difference 1 (RD1) antigens during the first 24 weeks of ARTResultsTB-IRIS and ART-associated tuberculosis occurred in 15 of 75 (20%) and 11 of 231 (4.8%) participants at risk, respectively. Greater increases in interferon γ (IFN-γ) and skin test responses to PPD were seen at week 24 and 12 in participants with TB-IRIS (P⩽.04), respectively. Raw IFN-γ responses to RD1 antigens and PPD corrected for pre-ART CD4+ T cell counts were higher at all time points in individuals with ART-associated tuberculosis (P

Original language	English
Pages (from-to)	1736-1745
Journal	The Journal of infectious diseases
Volume	200
Issue number	11
DOIs	https://doi.org/10.1086/644784
Publication status	Published - 2009

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Elliott, J. H., Vohith, K., Saramony, S., Savuth, C., Dara, C., Sarim, C., Huffam, S., Oelrichs, R., Sophea, P., Saphonn, V., Kaldor, J., Cooper, D. A., Vun, M. C., & French, M. (2009). Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy. The Journal of infectious diseases, 200(11), 1736-1745. https://doi.org/10.1086/644784

Elliott, J.H. ; Vohith, K. ; Saramony, S. ; Savuth, C. ; Dara, C. ; Sarim, C. ; Huffam, S. ; Oelrichs, R. ; Sophea, P. ; Saphonn, V. ; Kaldor, J. ; Cooper, D.A. ; Vun, M.C. ; French, Martyn. / Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy. In: The Journal of infectious diseases. 2009 ; Vol. 200, No. 11. pp. 1736-1745.

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abstract = "BackgroundIn many settings, the benefits of antiretroviral therapy (ART) are reduced by the high early incidence of tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)MethodsWe used tuberculin skin testing and the QuantiFERON-TB Gold In-Tube assay to investigate cellular immune responses to purified protein derivative (PPD) and region of difference 1 (RD1) antigens during the first 24 weeks of ARTResultsTB-IRIS and ART-associated tuberculosis occurred in 15 of 75 (20%) and 11 of 231 (4.8%) participants at risk, respectively. Greater increases in interferon γ (IFN-γ) and skin test responses to PPD were seen at week 24 and 12 in participants with TB-IRIS (P⩽.04), respectively. Raw IFN-γ responses to RD1 antigens and PPD corrected for pre-ART CD4+ T cell counts were higher at all time points in individuals with ART-associated tuberculosis (P",

author = "J.H. Elliott and K. Vohith and S. Saramony and C. Savuth and C. Dara and C. Sarim and S. Huffam and R. Oelrichs and P. Sophea and V. Saphonn and J. Kaldor and D.A. Cooper and M.C. Vun and Martyn French",

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Elliott, JH, Vohith, K, Saramony, S, Savuth, C, Dara, C, Sarim, C, Huffam, S, Oelrichs, R, Sophea, P, Saphonn, V, Kaldor, J, Cooper, DA, Vun, MC & French, M 2009, 'Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy', The Journal of infectious diseases, vol. 200, no. 11, pp. 1736-1745. https://doi.org/10.1086/644784

Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy. / Elliott, J.H.; Vohith, K.; Saramony, S.; Savuth, C.; Dara, C.; Sarim, C.; Huffam, S.; Oelrichs, R.; Sophea, P.; Saphonn, V.; Kaldor, J.; Cooper, D.A.; Vun, M.C.; French, Martyn.

In: The Journal of infectious diseases, Vol. 200, No. 11, 2009, p. 1736-1745.

Research output: Contribution to journal › Article

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T1 - Immunopathogenesis and Diagnosis of Tuberculosis and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome during Early Antiretroviral Therapy

AU - Elliott, J.H.

AU - Vohith, K.

AU - Saramony, S.

AU - Savuth, C.

AU - Dara, C.

AU - Sarim, C.

AU - Huffam, S.

AU - Oelrichs, R.

AU - Sophea, P.

AU - Saphonn, V.

AU - Kaldor, J.

AU - Cooper, D.A.

AU - Vun, M.C.

AU - French, Martyn

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AB - BackgroundIn many settings, the benefits of antiretroviral therapy (ART) are reduced by the high early incidence of tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS)MethodsWe used tuberculin skin testing and the QuantiFERON-TB Gold In-Tube assay to investigate cellular immune responses to purified protein derivative (PPD) and region of difference 1 (RD1) antigens during the first 24 weeks of ARTResultsTB-IRIS and ART-associated tuberculosis occurred in 15 of 75 (20%) and 11 of 231 (4.8%) participants at risk, respectively. Greater increases in interferon γ (IFN-γ) and skin test responses to PPD were seen at week 24 and 12 in participants with TB-IRIS (P⩽.04), respectively. Raw IFN-γ responses to RD1 antigens and PPD corrected for pre-ART CD4+ T cell counts were higher at all time points in individuals with ART-associated tuberculosis (P

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