Immunomodulatory and neuroprotective approaches including human mesenchymal precursor cell transplantation for spinal cord injury repair

Sarah Joy Lovett

Research output: ThesisDoctoral Thesis

270 Downloads (Pure)

Abstract

Spinal cord injury (SCI) often results in significant and long lasting functional impairments. Despite extensive research, there are currently no therapies that can effectively repair the damaged spinal cord. This thesis investigated novel neuroprotective strategies to prevent secondary tissue loss following injury, in combination with human mesenchymal precursor cell transplantation (hMPC). While there were no significant functional improvements with any therapy, there were significant morphological improvements with immune cell depletion and anti-inflammatory treatment, which was sometimes improved with hMPC transplantation. These results support the idea that combinatorial approaches may be more beneficial for SCI repair than individual therapies.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date14 Jun 2017
DOIs
Publication statusUnpublished - 2017

Fingerprint Dive into the research topics of 'Immunomodulatory and neuroprotective approaches including human mesenchymal precursor cell transplantation for spinal cord injury repair'. Together they form a unique fingerprint.

  • Cite this