Immunological determinants of immune restoration disease and immune recovery in HIV patients on antiretroviral therapy

Dino Bee Aik Tan

    Research output: ThesisDoctoral Thesis

    208 Downloads (Pure)

    Abstract

    [Truncated abstract] Antiretroviral therapy (ART) has improved the quality of life for human immunodeficiency virus (HIV)-infected patients by suppressing viral replication, allowing reconstitution of the immune system. However, patients initiating ART with advanced disease may experience immune restoration disease (IRD) or poor recovery of CD4+ T-cell numbers and/or functions. IRDs are attributed to immune responses that are immunopathological rather than protective. This thesis addresses possible causes of IRD and impaired CD4+ T-cell function in HIV patients who were very immunodeficient (starting ART with
    Original languageEnglish
    QualificationDoctor of Philosophy
    Publication statusUnpublished - 2011

    Fingerprint Dive into the research topics of 'Immunological determinants of immune restoration disease and immune recovery in HIV patients on antiretroviral therapy'. Together they form a unique fingerprint.

    Cite this