Immunogenicity and Safety of a Quadrivalent Meningococcal ACWY-tetanus Toxoid Conjugate Vaccine 6 Years After MenC Priming as Toddlers

Terry Nolan, Robert Booy, Helen S. Marshall, Peter Richmond, Michael Nissen, John B. Ziegler, Yaela Baine, Magali Traskine, Archana Jastorff, Marie Van der Wielen

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: We assessed immunogenicity, antibody persistence and safety of the meningococcal serogroups A, C, W and Y-tetanus toxoid (TT) conjugate vaccine (MenACWY-TT) in children primed as toddlers with MenC vaccine.

Methods: This open, multicenter extension study enrolled children 84-95 months of age who had received one dose of the combined Haemophilus influenzae type b (Hib)-MenC-TT conjugate vaccine (HibMenC group) or Hib-TT and monovalent MenC (MCC)-CRM 197 vaccines (Hib+ MCC group) at 12-18 months of age, in the primary study. All participants received one dose of Men-ACWY- TT. We assessed immunogenicity against MenA, MenC, MenW and MenY at 1 month and 2 years postvaccination by serum bactericidal assay using baby rabbit complement (rSBA). Safety and reactogenicity were evaluated.

Results: Six years post-MenC vaccination, = 1:8. At 1 month post-MenACWY-TT vaccination, vaccine response rates against all serogroups were high for both groups with >= 97.1% of children having rSBA >= 1: 8. Two years postvaccination, = 63.6% of children retained rSBA-MenA >= 1: 8, and >= 87.9% for other serogroups. Geometric mean titers for all serogroups declined at 2 years post-MenACWY-TT vaccination, but remained >= 13 times higher than prevaccination levels. For both groups, pain (

Conclusions: One dose of MenACWY-TT boosts protection against MenC in primed children, is safe and extends protection against MenA, MenW and MenY. Immunogenicity and safety were comparable in infants vaccinated with conjugated vaccine (HibMenC-TT) or the separate vaccines (Hib-TT and MCC-CRM 197).

Original languageEnglish
Pages (from-to)643-650
Number of pages8
JournalPediatric Infectious Disease Journal
Issue number6
Publication statusPublished - Jun 2019


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