Immunogenicity and reactogenicity of a combined hepatitis A-hepatitis B vaccine in adolescents

S C Thompson, M Norris

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


OBJECTIVE: To evaluate the immunogenicity and reactogenicity of two lots of a combined hepatitis A-hepatitis B vaccine (HAV, HBV) in healthy 15 to 18 year olds.

DESIGN: This was a double-blind, randomized clinical study. Vaccine was administered into the deltoid at 0, 1, and 6 months. Immunogenicity was assessed by anti-HAV and anti-HBs antibody levels at 2, 6, and 7 months after the first vaccine dose. Reactogenicity was assessed through use of 3-day diary cards following each vaccination, plus recording other unsolicited reactions.

RESULTS: A total of 160 adolescents were vaccinated; 155 who were seronegative for hepatitis A and B at baseline and who completed the study were included in the immunogenicity analysis. The vaccine was well tolerated; most side effects were local, of low intensity and short duration. Good immunogenicity was determined by antibody titers. High rates of seropositivity (99.4%) were achieved after two doses against HAV, and after three doses for anti-HBs (seroprotection = 98.7%).

CONCLUSIONS: This combination vaccine will be useful for immunizing selected high-risk groups in developed countries. In countries where endemicity is low for both diseases, targeting students prior to risk of acquisition would be a feasible preventive strategy.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalInternational Journal of Infectious Diseases
Issue number4
Publication statusPublished - 8 Oct 1998


Dive into the research topics of 'Immunogenicity and reactogenicity of a combined hepatitis A-hepatitis B vaccine in adolescents'. Together they form a unique fingerprint.

Cite this