Immuno-flowFISH in the assessment of paediatric acute lymphoblastic leukaemia

Carly George

doi:10.26182/z8a8-2550

Immuno-flowFISH in the assessment of paediatric acute lymphoblastic leukaemia

Carly George

UWA Medical School

Research output: Thesis › Master's Thesis

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Abstract

Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and may be characterised by multiple known recurrent genetic aberrations including aneuploidy and translocations. Immuno-flowFISH is a novel technique that offers the ability to simultaneously perform immunophenotyping and FISH on thousands of intact cells in suspension. This thesis provides a review of the existing literature on paediatric ALL, analyses the current relevant literature on combined flow cytometry and FISH, and presents results of the first proof-of-concept analysis of immune-flowFISH data for 25 paediatric B lineage ALL cases with known hyperdiploidy with trisomy4.

Original language	English
Qualification	Masters
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Erber, Wendy, Supervisor Fuller, Kathy, Supervisor Carter, Tina, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	23 May 2024
DOIs	https://doi.org/10.26182/z8a8-2550
Publication status	Unpublished - 2024

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10.26182/z8a8-2550

THESIS - MASTER OF CHILD HEALTH RESEARCH - GEORGE Carly Erin - 2024_
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title = "Immuno-flowFISH in the assessment of paediatric acute lymphoblastic leukaemia",

abstract = "Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and may be characterised by multiple known recurrent genetic aberrations including aneuploidy and translocations. Immuno-flowFISH is a novel technique that offers the ability to simultaneously perform immunophenotyping and FISH on thousands of intact cells in suspension. This thesis provides a review of the existing literature on paediatric ALL, analyses the current relevant literature on combined flow cytometry and FISH, and presents results of the first proof-of-concept analysis of immune-flowFISH data for 25 paediatric B lineage ALL cases with known hyperdiploidy with trisomy4.",

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N2 - Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and may be characterised by multiple known recurrent genetic aberrations including aneuploidy and translocations. Immuno-flowFISH is a novel technique that offers the ability to simultaneously perform immunophenotyping and FISH on thousands of intact cells in suspension. This thesis provides a review of the existing literature on paediatric ALL, analyses the current relevant literature on combined flow cytometry and FISH, and presents results of the first proof-of-concept analysis of immune-flowFISH data for 25 paediatric B lineage ALL cases with known hyperdiploidy with trisomy4.

AB - Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and may be characterised by multiple known recurrent genetic aberrations including aneuploidy and translocations. Immuno-flowFISH is a novel technique that offers the ability to simultaneously perform immunophenotyping and FISH on thousands of intact cells in suspension. This thesis provides a review of the existing literature on paediatric ALL, analyses the current relevant literature on combined flow cytometry and FISH, and presents results of the first proof-of-concept analysis of immune-flowFISH data for 25 paediatric B lineage ALL cases with known hyperdiploidy with trisomy4.

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KW - acute lymphoblastic leukaemia

KW - immuno-flowFISH

U2 - 10.26182/z8a8-2550

DO - 10.26182/z8a8-2550

M3 - Master's Thesis

ER -

Immuno-flowFISH in the assessment of paediatric acute lymphoblastic leukaemia

Abstract

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