Immunity to hepatitis C virus: stunned but not defeated

P Klenerman, Michaela Lucas, E Barnes, G Harcourt

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) readily causes a persistent infection, although some individuals spontaneously control infection. ‘Successful’ immune responses appear to be multi-specific and sustained-including a major role for CD4+ T cells. Some antiviral CD8+ T cells show reduced capacity to secrete antiviral cytokines either temporarily (‘stunning’) or in the long term (‘stunting’). The co-ordination of multiple immune effector functions may be required to gain control of HCV.

Original languageUndefined/Unknown
Pages (from-to)57-65
Number of pages9
JournalMicrobes and Infection
Volume4
Issue number1
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

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