IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis

W. Xu, R. Li, Y. Dai, A. Wu, H. Wang, C. Cheng, W. Qiu, Z. Lu, X. Zhong, Y. Shu, Allan Kermode, X. Hu

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Interleukin (IL)-22 secreting CD4+ T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4+IL-22+IL-17A+ T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS. © 2013 Elsevier B.V.
Original languageEnglish
Pages (from-to)87-91
JournalJournal of Neuroimmunology
Volume261
Issue number1-2
DOIs
Publication statusPublished - 2013

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