In vivo measurement of protein thiol oxidation in skeletal muscle

Research output: ThesisDoctoral Thesis

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Abstract

The aim of this work was to establish whether the thiol groups of proteins were a key target of reactive oxygen species as they are contributors to the pathology of many diseases. Through the development, refinement and application of novel biochemical tools, this work demonstrated that protein thiol oxidation was perturbed in people with Chronic Fatigue Syndrome. In canine and murine models of Duchenne Muscular Dystrophy, novel proteins undergoing thiol oxidation were identified. Using the novel tools developed in this work, it will be possible to better understand the mechanism by which reactive oxygen species cause pathology in disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Fournier, Paul, Supervisor
  • Arthur, Peter, Supervisor
Award date3 Apr 2020
DOIs
Publication statusUnpublished - 2020

Embargo information

  • Embargoed from 25/06/2020 to 01/07/2022. Made publicly available on 01/07/2022.

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