The aim of this work was to establish whether the thiol groups of proteins were a key target of reactive oxygen species as they are contributors to the pathology of many diseases. Through the development, refinement and application of novel biochemical tools, this work demonstrated that protein thiol oxidation was perturbed in people with Chronic Fatigue Syndrome. In canine and murine models of Duchenne Muscular Dystrophy, novel proteins undergoing thiol oxidation were identified. Using the novel tools developed in this work, it will be possible to better understand the mechanism by which reactive oxygen species cause pathology in disease.
|Doctor of Philosophy
|3 Apr 2020
|Unpublished - 2020
- Embargoed from 25/06/2020 to 01/07/2022. Made publicly available on 01/07/2022.