Helicobacter pylori infection induced genome instability and gastric cancer

Xiangyu Liu, Mohammad Irfan, Xingzhi Xu, Chin Yen Tay, Barry Marshall

Research output: Contribution to journalReview articlepeer-review

Abstract

Genome stability and integrity are constantly challenged by exogenous insults such as bacterial infections. When genome stability is perturbed, oncogenic transformation can ensue. Helicobacter pylori (H. pylori) infection is a driving factor of gastric cancer, which is the third leading cause of cancer-related mortality worldwide. Mechanistically, H. pylori infection drives inflammation and directly or indirectly induces DNA damage such as oxidative damage and double-strand breaks (DSBs) in host cells. In addition, the resulting genetic and/or epigenetic perturbations alter the choice of DNA repair pathways. These changes result in imprecise DNA repair, genomic instability as well as chromosomal aberrations that eventually lead to gastric carcinogenesis. In this review, we summarize the mechanisms how H. pylori infection cause DNA damage and alter the DNA damage response pathways in host cells. We highlight the relationship between H. pylori infection and genomic instability that can lead to gastric cancer and propose a potential strategy to interrupt gastric carcinogenesis.
Original languageEnglish
Pages (from-to)129-142
Number of pages14
Journal Genome Instability & Disease
Volume1
DOIs
Publication statusPublished - 21 Apr 2020

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