Abstract
Post-kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-gamma ( IFN-gamma). To study interferon-gamma pathways in PKDL, we genotyped 80 trios from the Masalit ethnic group for polymorphisms at-470 ins/delTT, -270T/C, -56T/C and +95T/C in IFNGR1 and at -179G/A and +874T/A in IFNG. No associations occurred at IFNG. Global association with haplotypes comprising all four markers at IFNGR1 (chi(2)(10df) 10df 21.97, P = 0.015) was observed, associated with a significant (chi(2)(1df) = 1df 4.54, P = 0.033) bias in transmission of the haplotype insTT T T T and less (chi(2)(1df) = 5.59, P = 0.018) than expected transmission of insTT C C C. When compared with data on malaria associations from Gambia, the results suggest a complex pattern of haplotypic variation at the IFNGR1 promoter locus associated with different infectious disease in African populations that reflect the complex roles of IFN-gamma in parasite killing versus inflammation and pathogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 75-78 |
| Journal | Genes and Immunity |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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