Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

M. Miyake; K. Yamashiro; Y. Tabara; K. Suda; S. Morooka; H. Nakanishi; C.C. Khor; P. Chen; F. Qiao; I. Nakata; Y. Akagi-Kurashige; N. Gotoh; A. Tsujikawa; A. Meguro; S. Kusuhara; O. Polasek; C. Hayward; A.F. Wright; H. Campbell; A.J. Richardson; M. Schäche; M. Takeuchi; David Mackey; A.W. Hewitt; G. Cuellar; Y. Shi; L. Huang; Z. Yang; K. Leung; P.Y.P. Kao; M. Yap; S. Yip; M. Moriyama; K. Ohno-Matsui; N. Mizuki; S. Macgregor; V. Vitart; T. Aung; S. Saw; E.S. Tai; T. Wong; C. Cheng; P.N. Baird; R. Yamada; F. Matsuda; N. Yoshimura

doi:10.1038/ncomms7689

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

M. Miyake, K. Yamashiro, Y. Tabara, K. Suda, S. Morooka, H. Nakanishi, C.C. Khor, P. Chen, F. Qiao, I. Nakata, Y. Akagi-Kurashige, N. Gotoh, A. Tsujikawa, A. Meguro, S. Kusuhara, O. Polasek, C. Hayward, A.F. Wright, H. Campbell, A.J. RichardsonM. Schäche, M. Takeuchi, David Mackey, A.W. Hewitt, G. Cuellar, Y. Shi, L. Huang, Z. Yang, K. Leung, P.Y.P. Kao, M. Yap, S. Yip, M. Moriyama, K. Ohno-Matsui, N. Mizuki, S. Macgregor, V. Vitart, T. Aung, S. Saw, E.S. Tai, T. Wong, C. Cheng, P.N. Baird, R. Yamada, F. Matsuda, N. Yoshimura

Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 × 10-13) and corneal curvature (Pmeta =2.9 × 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

Original language	English
Pages (from-to)	6689
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms7689
Publication status	Published - 2015

Access to Document

10.1038/ncomms7689

Cite this

Miyake, M., Yamashiro, K., Tabara, Y., Suda, K., Morooka, S., Nakanishi, H., Khor, C. C., Chen, P., Qiao, F., Nakata, I., Akagi-Kurashige, Y., Gotoh, N., Tsujikawa, A., Meguro, A., Kusuhara, S., Polasek, O., Hayward, C., Wright, A. F., Campbell, H., ... Yoshimura, N. (2015). Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia. Nature Communications, 6, 6689. https://doi.org/10.1038/ncomms7689

@article{9abb641260094620b92fd98ceea7f2a0,

title = "Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia",

abstract = "{\textcopyright} 2015 Macmillan Publishers Limited. All rights reserved. Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 × 10-13) and corneal curvature (Pmeta =2.9 × 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.",

author = "M. Miyake and K. Yamashiro and Y. Tabara and K. Suda and S. Morooka and H. Nakanishi and C.C. Khor and P. Chen and F. Qiao and I. Nakata and Y. Akagi-Kurashige and N. Gotoh and A. Tsujikawa and A. Meguro and S. Kusuhara and O. Polasek and C. Hayward and A.F. Wright and H. Campbell and A.J. Richardson and M. Sch{\"a}che and M. Takeuchi and David Mackey and A.W. Hewitt and G. Cuellar and Y. Shi and L. Huang and Z. Yang and K. Leung and P.Y.P. Kao and M. Yap and S. Yip and M. Moriyama and K. Ohno-Matsui and N. Mizuki and S. Macgregor and V. Vitart and T. Aung and S. Saw and E.S. Tai and T. Wong and C. Cheng and P.N. Baird and R. Yamada and F. Matsuda and N. Yoshimura",

year = "2015",

doi = "10.1038/ncomms7689",

language = "English",

volume = "6",

pages = "6689",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group - Macmillan Publishers",

}

Miyake, M, Yamashiro, K, Tabara, Y, Suda, K, Morooka, S, Nakanishi, H, Khor, CC, Chen, P, Qiao, F, Nakata, I, Akagi-Kurashige, Y, Gotoh, N, Tsujikawa, A, Meguro, A, Kusuhara, S, Polasek, O, Hayward, C, Wright, AF, Campbell, H, Richardson, AJ, Schäche, M, Takeuchi, M, Mackey, D, Hewitt, AW, Cuellar, G, Shi, Y, Huang, L, Yang, Z, Leung, K, Kao, PYP, Yap, M, Yip, S, Moriyama, M, Ohno-Matsui, K, Mizuki, N, Macgregor, S, Vitart, V, Aung, T, Saw, S, Tai, ES, Wong, T, Cheng, C, Baird, PN, Yamada, R, Matsuda, F & Yoshimura, N 2015, 'Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia', Nature Communications, vol. 6, pp. 6689. https://doi.org/10.1038/ncomms7689

TY - JOUR

T1 - Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

AU - Miyake, M.

AU - Yamashiro, K.

AU - Tabara, Y.

AU - Suda, K.

AU - Morooka, S.

AU - Nakanishi, H.

AU - Khor, C.C.

AU - Chen, P.

AU - Qiao, F.

AU - Nakata, I.

AU - Akagi-Kurashige, Y.

AU - Gotoh, N.

AU - Tsujikawa, A.

AU - Meguro, A.

AU - Kusuhara, S.

AU - Polasek, O.

AU - Hayward, C.

AU - Wright, A.F.

AU - Campbell, H.

AU - Richardson, A.J.

AU - Schäche, M.

AU - Takeuchi, M.

AU - Mackey, David

AU - Hewitt, A.W.

AU - Cuellar, G.

AU - Shi, Y.

AU - Huang, L.

AU - Yang, Z.

AU - Leung, K.

AU - Kao, P.Y.P.

AU - Yap, M.

AU - Yip, S.

AU - Moriyama, M.

AU - Ohno-Matsui, K.

AU - Mizuki, N.

AU - Macgregor, S.

AU - Vitart, V.

AU - Aung, T.

AU - Saw, S.

AU - Tai, E.S.

AU - Wong, T.

AU - Cheng, C.

AU - Baird, P.N.

AU - Yamada, R.

AU - Matsuda, F.

AU - Yoshimura, N.

PY - 2015

Y1 - 2015

N2 - © 2015 Macmillan Publishers Limited. All rights reserved. Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 × 10-13) and corneal curvature (Pmeta =2.9 × 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

AB - © 2015 Macmillan Publishers Limited. All rights reserved. Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 × 10-13) and corneal curvature (Pmeta =2.9 × 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

U2 - 10.1038/ncomms7689

DO - 10.1038/ncomms7689

M3 - Article

C2 - 25823570

SN - 2041-1723

VL - 6

SP - 6689

JO - Nature Communications

JF - Nature Communications

ER -

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Abstract

Access to Document

Fingerprint

Cite this