Identification of genes regulating osteoarthritis development using a mouse phenotype library

Research output: ThesisDoctoral Thesis

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Abstract

Osteoarthritis (OA) is a degenerative joint disease that affects a significant proportion of the population. It has been hypothesised that spontaneous forms of OA have a heritable component. Therefore, investigation of genes associated with the disease are important. Using the Collaborative Cross mouse library, we were able to screen for spontaneous OA phenotypes and identify genetic loci associated with OA. Seven loci, two reaching genome wide significance, were identified. A range of genes were identified, a subset of which were correlated in human OA datasets. These genes may be used for future studies into diagnostic and therapeutic targets for OA.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date26 Nov 2018
DOIs
Publication statusUnpublished - 2018

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