Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

S. Ulyanchenko; K.E. O'Neill; T. Medley; A.M. Farley; H.J. Vaidya; Alistair Cook; N.F. Blair; C.C. Blackburn

doi:10.1016/j.celrep.2016.02.080

Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

S. Ulyanchenko, K.E. O'Neill, T. Medley, A.M. Farley, H.J. Vaidya, Alistair Cook, N.F. Blair, C.C. Blackburn

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Abstract

© 2016 The Authors. Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam+UEA1-Ly-51+PLET1+MHC class IIhi, which comprises

Original language	English
Pages (from-to)	2819-2832
Number of pages	14
Journal	Cell Reports
Volume	14
Issue number	12
Early online date	17 Mar 2016
DOIs	https://doi.org/10.1016/j.celrep.2016.02.080
Publication status	Published - 29 Mar 2016

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10.1016/j.celrep.2016.02.080Licence: CC BY-NC-ND

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AU - Ulyanchenko, S.

AU - O'Neill, K.E.

AU - Medley, T.

AU - Farley, A.M.

AU - Vaidya, H.J.

AU - Cook, Alistair

AU - Blair, N.F.

AU - Blackburn, C.C.

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AB - © 2016 The Authors. Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam+UEA1-Ly-51+PLET1+MHC class IIhi, which comprises

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DO - 10.1016/j.celrep.2016.02.080

M3 - Article

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JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

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Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

Abstract

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