Identification and functional characterisation of non-canonical DNA methylation readers in the mammalian brain

Sufyaan Mohamed

Research output: ThesisDoctoral Thesis

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Abstract

DNA methylation is a covalent modification occurring predominantly in the CG dinucleotide context within mammals (mCG), but non-CG contexts (mCH, where H = A, C or T) exist within restricted cell types. In the brain, mCH accumulates to become the dominant form of DNA methylation in adult neurons, coinciding with synaptogenesis. Many proteins binding to mCG have been identified and characterised, but this is lacking for mCA. This PhD constitutes the first study that comprehensively identifies proteins that bind to CG and non-CG DNA methylation in human and mouse brain, providing promising protein candidates for future studies to build upon.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lister, Ryan, Supervisor
  • Bogdanovic, Ozren, Supervisor
  • Karpievitch, Yuliya, Supervisor
  • Small, Ian, Supervisor
  • Murcha, Monika, Supervisor
Thesis sponsors
Award date14 May 2021
DOIs
Publication statusUnpublished - 2021

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