Identical subchondral bone microarchitecture pattern with increasedbone resorption in rheumatoid arthritis as compared to osteoarthritis

G. Li, Y. Ma, Tak Sum Cheng, Euphemie Landao-Bassonga, A. Qin, Nathan Pavlos, C. Zhang, Q. Zheng, Minghao Zheng

Research output: Contribution to journalArticle

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Abstract

© 2014 Osteoarthritis Research Society International. Objectives: To analyze the differences in microarchitecture and bone remodeling of subchondral bone in femoral heads from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Designs: Peri-articular bone samples, including subchondral trabecular bone (STB) and deeper trabecular bone (DTB) were extracted from the load-bearing region of femoral heads from 20 patients with RA and 40 patients with OA during hip replacement surgery. Micro-CT, histomorphometry and backscatter scanning electron microscopy (BSEM) were performed to assess microarchitecture and bone histology parameters. Results: In both RA and OA, STB showed more sclerotic microarchitecture and more active bone remodeling, compared to DTB. RA and OA showed similar microarchitecture characteristics in both STB and DTB, despite STB in RA exhibiting higher bone resorption. In addition, there was no difference in the frequency of bone cysts in STB between RA and OA. In STB, the trabecular bone surrounding subchondral bone cysts (Cys-Tb) was more sclerotic than the trabecular bone found distant to cysts (Peri-Tb), with a higher level of bone remodeling. Both Cys-Tb region and Peri-Tb region were detected to have similar microarchitectural and bone remodeling characteristics in RA and OA. Conclusions: Apart from higher bone resorption in the general subchondral bone of RA samples, the peri-articular bone exhibited similar microarchitectural and bone remodeling characteristics in RA and OA.
Original languageEnglish
Pages (from-to)2083-2092
JournalOsteoarthritis and Cartilage
Volume22
Issue number12
DOIs
Publication statusPublished - 2014

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Osteoarthritis
Rheumatoid Arthritis
Bone
Bone and Bones
Bone Remodeling
Bone Resorption
Thigh
Cancellous Bone
Joints
Hip Osteoarthritis
Weight-Bearing
Electron Scanning Microscopy
Histology
Bearings (structural)

Cite this

@article{21f0df7e78264694a5585cc8e75ca57c,
title = "Identical subchondral bone microarchitecture pattern with increasedbone resorption in rheumatoid arthritis as compared to osteoarthritis",
abstract = "{\circledC} 2014 Osteoarthritis Research Society International. Objectives: To analyze the differences in microarchitecture and bone remodeling of subchondral bone in femoral heads from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Designs: Peri-articular bone samples, including subchondral trabecular bone (STB) and deeper trabecular bone (DTB) were extracted from the load-bearing region of femoral heads from 20 patients with RA and 40 patients with OA during hip replacement surgery. Micro-CT, histomorphometry and backscatter scanning electron microscopy (BSEM) were performed to assess microarchitecture and bone histology parameters. Results: In both RA and OA, STB showed more sclerotic microarchitecture and more active bone remodeling, compared to DTB. RA and OA showed similar microarchitecture characteristics in both STB and DTB, despite STB in RA exhibiting higher bone resorption. In addition, there was no difference in the frequency of bone cysts in STB between RA and OA. In STB, the trabecular bone surrounding subchondral bone cysts (Cys-Tb) was more sclerotic than the trabecular bone found distant to cysts (Peri-Tb), with a higher level of bone remodeling. Both Cys-Tb region and Peri-Tb region were detected to have similar microarchitectural and bone remodeling characteristics in RA and OA. Conclusions: Apart from higher bone resorption in the general subchondral bone of RA samples, the peri-articular bone exhibited similar microarchitectural and bone remodeling characteristics in RA and OA.",
author = "G. Li and Y. Ma and Cheng, {Tak Sum} and Euphemie Landao-Bassonga and A. Qin and Nathan Pavlos and C. Zhang and Q. Zheng and Minghao Zheng",
year = "2014",
doi = "10.1016/j.joca.2014.08.015",
language = "English",
volume = "22",
pages = "2083--2092",
journal = "Journal of Osteoarthritis and Cartilage",
issn = "1063-4584",
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}

Identical subchondral bone microarchitecture pattern with increasedbone resorption in rheumatoid arthritis as compared to osteoarthritis. / Li, G.; Ma, Y.; Cheng, Tak Sum; Landao-Bassonga, Euphemie; Qin, A.; Pavlos, Nathan; Zhang, C.; Zheng, Q.; Zheng, Minghao.

In: Osteoarthritis and Cartilage, Vol. 22, No. 12, 2014, p. 2083-2092.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Identical subchondral bone microarchitecture pattern with increasedbone resorption in rheumatoid arthritis as compared to osteoarthritis

AU - Li, G.

AU - Ma, Y.

AU - Cheng, Tak Sum

AU - Landao-Bassonga, Euphemie

AU - Qin, A.

AU - Pavlos, Nathan

AU - Zhang, C.

AU - Zheng, Q.

AU - Zheng, Minghao

PY - 2014

Y1 - 2014

N2 - © 2014 Osteoarthritis Research Society International. Objectives: To analyze the differences in microarchitecture and bone remodeling of subchondral bone in femoral heads from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Designs: Peri-articular bone samples, including subchondral trabecular bone (STB) and deeper trabecular bone (DTB) were extracted from the load-bearing region of femoral heads from 20 patients with RA and 40 patients with OA during hip replacement surgery. Micro-CT, histomorphometry and backscatter scanning electron microscopy (BSEM) were performed to assess microarchitecture and bone histology parameters. Results: In both RA and OA, STB showed more sclerotic microarchitecture and more active bone remodeling, compared to DTB. RA and OA showed similar microarchitecture characteristics in both STB and DTB, despite STB in RA exhibiting higher bone resorption. In addition, there was no difference in the frequency of bone cysts in STB between RA and OA. In STB, the trabecular bone surrounding subchondral bone cysts (Cys-Tb) was more sclerotic than the trabecular bone found distant to cysts (Peri-Tb), with a higher level of bone remodeling. Both Cys-Tb region and Peri-Tb region were detected to have similar microarchitectural and bone remodeling characteristics in RA and OA. Conclusions: Apart from higher bone resorption in the general subchondral bone of RA samples, the peri-articular bone exhibited similar microarchitectural and bone remodeling characteristics in RA and OA.

AB - © 2014 Osteoarthritis Research Society International. Objectives: To analyze the differences in microarchitecture and bone remodeling of subchondral bone in femoral heads from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Designs: Peri-articular bone samples, including subchondral trabecular bone (STB) and deeper trabecular bone (DTB) were extracted from the load-bearing region of femoral heads from 20 patients with RA and 40 patients with OA during hip replacement surgery. Micro-CT, histomorphometry and backscatter scanning electron microscopy (BSEM) were performed to assess microarchitecture and bone histology parameters. Results: In both RA and OA, STB showed more sclerotic microarchitecture and more active bone remodeling, compared to DTB. RA and OA showed similar microarchitecture characteristics in both STB and DTB, despite STB in RA exhibiting higher bone resorption. In addition, there was no difference in the frequency of bone cysts in STB between RA and OA. In STB, the trabecular bone surrounding subchondral bone cysts (Cys-Tb) was more sclerotic than the trabecular bone found distant to cysts (Peri-Tb), with a higher level of bone remodeling. Both Cys-Tb region and Peri-Tb region were detected to have similar microarchitectural and bone remodeling characteristics in RA and OA. Conclusions: Apart from higher bone resorption in the general subchondral bone of RA samples, the peri-articular bone exhibited similar microarchitectural and bone remodeling characteristics in RA and OA.

U2 - 10.1016/j.joca.2014.08.015

DO - 10.1016/j.joca.2014.08.015

M3 - Article

VL - 22

SP - 2083

EP - 2092

JO - Journal of Osteoarthritis and Cartilage

JF - Journal of Osteoarthritis and Cartilage

SN - 1063-4584

IS - 12

ER -