Ibrutinib for central nervous system lymphoma: the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience

Katharine L. Lewis; Collin K. Chin; Kate Manos; John Casey; Nada Hamad; Julie Crawford; Shir Jing Ho; Samar Issa; Andrew Grigg; Peter Wood; Maher K. Gandhi; Bryan Do; Loretta Nastoupil; Eliza A. Hawkes; Chan Y. Cheah

doi:10.1111/bjh.16946

Ibrutinib for central nervous system lymphoma: the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience

Katharine L. Lewis, Collin K. Chin, Kate Manos, John Casey, Nada Hamad, Julie Crawford, Shir Jing Ho, Samar Issa, Andrew Grigg, Peter Wood, Maher K. Gandhi, Bryan Do, Loretta Nastoupil, Eliza A. Hawkes, Chan Y. Cheah

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32 Citations (Scopus)

Abstract

Primary and secondary central nervous system lymphomas (PCNSL/SCNSL) are aggressive rare malignancies with dismal outcomes. Encouraging data have emerged from Phase I/II clinical trials treating relapsed/refractory PCNSL/SCNSL with ibrutinib. We analysed 33 patients who received ibrutinib, alone or with other therapies, for PCNSL (n = 9) or SCNSL (n = 24). The objective response rate was 58% (complete response 55%). The median progression-free survival and overall survival for patients with PCNSL were both 3·1 months; for SCNSL, 10·2 and 11·5 months respectively. Only one invasive fungal infection was observed, despite concurrent or recent use of dexamethasone 8–16 mg daily in 14 patients (42%). Ibrutinib has encouraging activity in these aggressive malignancies.

Original language	English
Pages (from-to)	1049-1053
Number of pages	5
Journal	British Journal of Haematology
Volume	192
Issue number	6
Early online date	16 Jul 2020
DOIs	https://doi.org/10.1111/bjh.16946
Publication status	Published - Mar 2021

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Lewis, K. L., Chin, C. K., Manos, K., Casey, J., Hamad, N., Crawford, J., Ho, S. J., Issa, S., Grigg, A., Wood, P., Gandhi, M. K., Do, B., Nastoupil, L., Hawkes, E. A., & Cheah, C. Y. (2021). Ibrutinib for central nervous system lymphoma: the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience. British Journal of Haematology, 192(6), 1049-1053. https://doi.org/10.1111/bjh.16946

@article{84d043ddbf4e4a0d8db3055084a05603,

title = "Ibrutinib for central nervous system lymphoma: the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience",

abstract = "Primary and secondary central nervous system lymphomas (PCNSL/SCNSL) are aggressive rare malignancies with dismal outcomes. Encouraging data have emerged from Phase I/II clinical trials treating relapsed/refractory PCNSL/SCNSL with ibrutinib. We analysed 33 patients who received ibrutinib, alone or with other therapies, for PCNSL (n = 9) or SCNSL (n = 24). The objective response rate was 58% (complete response 55%). The median progression-free survival and overall survival for patients with PCNSL were both 3·1 months; for SCNSL, 10·2 and 11·5 months respectively. Only one invasive fungal infection was observed, despite concurrent or recent use of dexamethasone 8–16 mg daily in 14 patients (42%). Ibrutinib has encouraging activity in these aggressive malignancies.",

keywords = "BTK inhibitor, central nervous system, ibrutinib, lymphoma, novel",

author = "Lewis, {Katharine L.} and Chin, {Collin K.} and Kate Manos and John Casey and Nada Hamad and Julie Crawford and Ho, {Shir Jing} and Samar Issa and Andrew Grigg and Peter Wood and Gandhi, {Maher K.} and Bryan Do and Loretta Nastoupil and Hawkes, {Eliza A.} and Cheah, {Chan Y.}",

year = "2021",

month = mar,

doi = "10.1111/bjh.16946",

language = "English",

volume = "192",

pages = "1049--1053",

journal = "British Journal of Haematology",

issn = "0007-1048",

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Lewis, KL, Chin, CK, Manos, K, Casey, J, Hamad, N, Crawford, J, Ho, SJ, Issa, S, Grigg, A, Wood, P, Gandhi, MK, Do, B, Nastoupil, L, Hawkes, EA & Cheah, CY 2021, 'Ibrutinib for central nervous system lymphoma: the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience', British Journal of Haematology, vol. 192, no. 6, pp. 1049-1053. https://doi.org/10.1111/bjh.16946

TY - JOUR

T1 - Ibrutinib for central nervous system lymphoma

T2 - the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience

AU - Lewis, Katharine L.

AU - Chin, Collin K.

AU - Manos, Kate

AU - Casey, John

AU - Hamad, Nada

AU - Crawford, Julie

AU - Ho, Shir Jing

AU - Issa, Samar

AU - Grigg, Andrew

AU - Wood, Peter

AU - Gandhi, Maher K.

AU - Do, Bryan

AU - Nastoupil, Loretta

AU - Hawkes, Eliza A.

AU - Cheah, Chan Y.

PY - 2021/3

Y1 - 2021/3

N2 - Primary and secondary central nervous system lymphomas (PCNSL/SCNSL) are aggressive rare malignancies with dismal outcomes. Encouraging data have emerged from Phase I/II clinical trials treating relapsed/refractory PCNSL/SCNSL with ibrutinib. We analysed 33 patients who received ibrutinib, alone or with other therapies, for PCNSL (n = 9) or SCNSL (n = 24). The objective response rate was 58% (complete response 55%). The median progression-free survival and overall survival for patients with PCNSL were both 3·1 months; for SCNSL, 10·2 and 11·5 months respectively. Only one invasive fungal infection was observed, despite concurrent or recent use of dexamethasone 8–16 mg daily in 14 patients (42%). Ibrutinib has encouraging activity in these aggressive malignancies.

AB - Primary and secondary central nervous system lymphomas (PCNSL/SCNSL) are aggressive rare malignancies with dismal outcomes. Encouraging data have emerged from Phase I/II clinical trials treating relapsed/refractory PCNSL/SCNSL with ibrutinib. We analysed 33 patients who received ibrutinib, alone or with other therapies, for PCNSL (n = 9) or SCNSL (n = 24). The objective response rate was 58% (complete response 55%). The median progression-free survival and overall survival for patients with PCNSL were both 3·1 months; for SCNSL, 10·2 and 11·5 months respectively. Only one invasive fungal infection was observed, despite concurrent or recent use of dexamethasone 8–16 mg daily in 14 patients (42%). Ibrutinib has encouraging activity in these aggressive malignancies.

KW - BTK inhibitor

KW - central nervous system

KW - ibrutinib

KW - lymphoma

KW - novel

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U2 - 10.1111/bjh.16946

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AN - SCOPUS:85088103694

SN - 0007-1048

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EP - 1053

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Ibrutinib for central nervous system lymphoma: the Australasian Lymphoma Alliance/MD Anderson Cancer Center experience

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