Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells

S.T.F. Hsiao, Z. Lokmic, H.M. Peshavariya, K.M. Abberton, G.J. Dusting, S.Y. Lim, Rodney Dilley

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    Abstract

    Human adipose-derived stem cells (ASCs) secrete cytokines and growth factors that can be harnessed in a paracrine fashion for promotion of angiogenesis, cell survival, and activation of endogenous stem cells. We recently showed that hypoxia is a powerful stimulus for an angiogenic activity from ASCs in vitro and here we investigate the biological significance of this paracrine activity in an in vivo angiogenesis model. A single in vitro exposure of ASCs to severe hypoxia (
    Original languageEnglish
    Pages (from-to)1614-1623
    JournalStem Cells and Development
    Volume22
    Issue number10
    DOIs
    Publication statusPublished - 2013

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