Hypoxia Inhibits Activin A Production by Term Villous Trophoblast In Vitro

M. Blumenstein, M.D. Mitchell, N.P. Groome, Jeffrey Keelan

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    23 Citations (Scopus)


    Elevated activin A and inhibin A levels have been associated with pre-eclampsia, a pregnancy-related disorder associated with placental hypoxaemia. We investigated the effect of in Nitro hypoxia on the production of inhibin A, activin A and its binding protein follistatin in term villous placental explants (n = +-7) and trophoblast monolayer cultures (n = 4). Explants and trophoblasts were incubated for 24-72 h under either normoxic (21 per cent 02) or hypoxic (2 per cent 0,) conditions. Production of activin A, inhibin A, and follistatin was determined by specific ELISA. After 48 h of hypoxia, villous explants exhibited a significant reduction in activin in A production rates to 53.2 +/- 8.9 per cent (mean +/- SEM, P
    Original languageEnglish
    Pages (from-to)735-741
    Publication statusPublished - 2002


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