Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents

Chi Le-Ha, C.E. Herbison, Lawrence Beilin, Sally Burrows, David Henley, S.J. Lye, S.G. Matthews, Craig Pennell, Trevor Mori

    Research output: Contribution to journalArticle

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    Abstract

    © 2016 Elsevier Ltd. Background: Activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with higher levels of cardiovascular (CVD) risk factors in adults. This study aimed to assess the relation between measures of HPA axis activity under resting conditions and CVD risk factors in a general population of adolescents at 17 years. Methods: A total of 1134 adolescents from the Western Australian Pregnancy Cohort (Raine) Study had phenotypic and socio-demographic data. The associations between HPA axis measures (plasma ACTH, total cortisol, calculated free cortisol, corticosteroid binding globulin (CBG), and salivary cortisol) and a range of cardiovascular risk factors were examined using multivariable linear regression models, with adjustment for gender, adiposity, birth weight, gestational age, and socio-behavioural factors. Results: Plasma total cortisol was positively associated with systolic blood pressure (SBP) (p = 0.011), total cholesterol, HDL-cholesterol, and triglycerides (all p <0.001), and hs-CRP (p = 0.047). Salivary cortisol was associated positively with HDL-C (p = 0.033) and negatively with LDL-cholesterol (p = 0.016); plasma calculated free cortisol was positively associated with triglycerides (p = 0.006); plasma CBG was positively associated with total cholesterol and HDL-cholesterol (both p <0.001), LDL-cholesterol (p = 0.022), and hs-CRP (p = 0.001). After correction for multiple comparisons, significant associations remained for total cortisol with total cholesterol, HDL-C, and triglycerides; for calculated free cortisol with triglycerides; and for CBG with HDL-C, total cholesterol, and hs-CRP. Plasma ACTH was not associated with any cardiovascular risk factor. There was no association between BMI and any measure of HPA axis activity. Conclusion: In an adolescent population, HPA axis measures under resting conditions are associated with a range of CVD risk factors. Clarification of the mechanisms underlying these associations in adolescence would be an important step in understanding the evolution of adult CVD.
    Original languageEnglish
    Pages (from-to)118-124
    Number of pages7
    JournalPsychoneuroendocrinology
    Volume66
    Early online date9 Jan 2016
    DOIs
    Publication statusPublished - Apr 2016

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    Hydrocortisone
    Transcortin
    Triglycerides
    HDL Cholesterol
    Cholesterol
    Adrenocorticotropic Hormone
    LDL Cholesterol
    Linear Models
    Blood Pressure
    Adiposity
    Birth Weight
    Population
    Gestational Age
    Cohort Studies
    Demography
    Pregnancy

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    @article{dc6cdd4e2cdc4260b7de61dabaedce2e,
    title = "Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents",
    abstract = "{\circledC} 2016 Elsevier Ltd. Background: Activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with higher levels of cardiovascular (CVD) risk factors in adults. This study aimed to assess the relation between measures of HPA axis activity under resting conditions and CVD risk factors in a general population of adolescents at 17 years. Methods: A total of 1134 adolescents from the Western Australian Pregnancy Cohort (Raine) Study had phenotypic and socio-demographic data. The associations between HPA axis measures (plasma ACTH, total cortisol, calculated free cortisol, corticosteroid binding globulin (CBG), and salivary cortisol) and a range of cardiovascular risk factors were examined using multivariable linear regression models, with adjustment for gender, adiposity, birth weight, gestational age, and socio-behavioural factors. Results: Plasma total cortisol was positively associated with systolic blood pressure (SBP) (p = 0.011), total cholesterol, HDL-cholesterol, and triglycerides (all p <0.001), and hs-CRP (p = 0.047). Salivary cortisol was associated positively with HDL-C (p = 0.033) and negatively with LDL-cholesterol (p = 0.016); plasma calculated free cortisol was positively associated with triglycerides (p = 0.006); plasma CBG was positively associated with total cholesterol and HDL-cholesterol (both p <0.001), LDL-cholesterol (p = 0.022), and hs-CRP (p = 0.001). After correction for multiple comparisons, significant associations remained for total cortisol with total cholesterol, HDL-C, and triglycerides; for calculated free cortisol with triglycerides; and for CBG with HDL-C, total cholesterol, and hs-CRP. Plasma ACTH was not associated with any cardiovascular risk factor. There was no association between BMI and any measure of HPA axis activity. Conclusion: In an adolescent population, HPA axis measures under resting conditions are associated with a range of CVD risk factors. Clarification of the mechanisms underlying these associations in adolescence would be an important step in understanding the evolution of adult CVD.",
    author = "Chi Le-Ha and C.E. Herbison and Lawrence Beilin and Sally Burrows and David Henley and S.J. Lye and S.G. Matthews and Craig Pennell and Trevor Mori",
    year = "2016",
    month = "4",
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    language = "English",
    volume = "66",
    pages = "118--124",
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    Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents. / Le-Ha, Chi; Herbison, C.E.; Beilin, Lawrence; Burrows, Sally; Henley, David; Lye, S.J.; Matthews, S.G.; Pennell, Craig; Mori, Trevor.

    In: Psychoneuroendocrinology, Vol. 66, 04.2016, p. 118-124.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents

    AU - Le-Ha, Chi

    AU - Herbison, C.E.

    AU - Beilin, Lawrence

    AU - Burrows, Sally

    AU - Henley, David

    AU - Lye, S.J.

    AU - Matthews, S.G.

    AU - Pennell, Craig

    AU - Mori, Trevor

    PY - 2016/4

    Y1 - 2016/4

    N2 - © 2016 Elsevier Ltd. Background: Activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with higher levels of cardiovascular (CVD) risk factors in adults. This study aimed to assess the relation between measures of HPA axis activity under resting conditions and CVD risk factors in a general population of adolescents at 17 years. Methods: A total of 1134 adolescents from the Western Australian Pregnancy Cohort (Raine) Study had phenotypic and socio-demographic data. The associations between HPA axis measures (plasma ACTH, total cortisol, calculated free cortisol, corticosteroid binding globulin (CBG), and salivary cortisol) and a range of cardiovascular risk factors were examined using multivariable linear regression models, with adjustment for gender, adiposity, birth weight, gestational age, and socio-behavioural factors. Results: Plasma total cortisol was positively associated with systolic blood pressure (SBP) (p = 0.011), total cholesterol, HDL-cholesterol, and triglycerides (all p <0.001), and hs-CRP (p = 0.047). Salivary cortisol was associated positively with HDL-C (p = 0.033) and negatively with LDL-cholesterol (p = 0.016); plasma calculated free cortisol was positively associated with triglycerides (p = 0.006); plasma CBG was positively associated with total cholesterol and HDL-cholesterol (both p <0.001), LDL-cholesterol (p = 0.022), and hs-CRP (p = 0.001). After correction for multiple comparisons, significant associations remained for total cortisol with total cholesterol, HDL-C, and triglycerides; for calculated free cortisol with triglycerides; and for CBG with HDL-C, total cholesterol, and hs-CRP. Plasma ACTH was not associated with any cardiovascular risk factor. There was no association between BMI and any measure of HPA axis activity. Conclusion: In an adolescent population, HPA axis measures under resting conditions are associated with a range of CVD risk factors. Clarification of the mechanisms underlying these associations in adolescence would be an important step in understanding the evolution of adult CVD.

    AB - © 2016 Elsevier Ltd. Background: Activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with higher levels of cardiovascular (CVD) risk factors in adults. This study aimed to assess the relation between measures of HPA axis activity under resting conditions and CVD risk factors in a general population of adolescents at 17 years. Methods: A total of 1134 adolescents from the Western Australian Pregnancy Cohort (Raine) Study had phenotypic and socio-demographic data. The associations between HPA axis measures (plasma ACTH, total cortisol, calculated free cortisol, corticosteroid binding globulin (CBG), and salivary cortisol) and a range of cardiovascular risk factors were examined using multivariable linear regression models, with adjustment for gender, adiposity, birth weight, gestational age, and socio-behavioural factors. Results: Plasma total cortisol was positively associated with systolic blood pressure (SBP) (p = 0.011), total cholesterol, HDL-cholesterol, and triglycerides (all p <0.001), and hs-CRP (p = 0.047). Salivary cortisol was associated positively with HDL-C (p = 0.033) and negatively with LDL-cholesterol (p = 0.016); plasma calculated free cortisol was positively associated with triglycerides (p = 0.006); plasma CBG was positively associated with total cholesterol and HDL-cholesterol (both p <0.001), LDL-cholesterol (p = 0.022), and hs-CRP (p = 0.001). After correction for multiple comparisons, significant associations remained for total cortisol with total cholesterol, HDL-C, and triglycerides; for calculated free cortisol with triglycerides; and for CBG with HDL-C, total cholesterol, and hs-CRP. Plasma ACTH was not associated with any cardiovascular risk factor. There was no association between BMI and any measure of HPA axis activity. Conclusion: In an adolescent population, HPA axis measures under resting conditions are associated with a range of CVD risk factors. Clarification of the mechanisms underlying these associations in adolescence would be an important step in understanding the evolution of adult CVD.

    U2 - 10.1016/j.psyneuen.2016.01.002

    DO - 10.1016/j.psyneuen.2016.01.002

    M3 - Article

    VL - 66

    SP - 118

    EP - 124

    JO - Psychoneuroendocrinology

    JF - Psychoneuroendocrinology

    SN - 0306-4530

    ER -