Hypermethylation of the Myogenic Gene Myf-3 in Human Breast Carcinomas

The methylation status of Myf-3 was studied in 34 human primary breast carcinomas and 9 normal breast tissues. One third of the carcinomas and 9 normal breast tissues. One third of the carcinomas contained hypermethylated Myf-3. All normal tissues contained unmethylated Myf-3. Myf-3 hypermethylation was more common in poorly differentiated grade 3 tumors than in better differentiated grade 1 and 2 tumours.