Hypermethylation of the Myf-3 Gene in Human Colorectal Cancer

Barry Iacopetta, D. Harmon, D.V. Spagnolo, Anthony House, Peter Kay

Research output: Contribution to journalArticlepeer-review

11 Citations (Web of Science)

Abstract

Abnormal methylation of DNA is one of the earliest detectable changes in human tumours. We investigated hypermethylation of the Myf-3 gene, the human homolog of the mouse myogenic gene Myo-D1, in colorectal adenomas and adenocarcinomas. Histologically normal gut mucosa from colorectal cancer patients showed moderately higher levels of methylation than in other normal tissues. Varying degrees of Myf-3 hypermethylation were found in all five adenomas and eight adenocarcinomas examined. Carcinomas arising from within adenomas generally showed a decrease in both the heterogeneity and intensity of Myf-3 methylation. Regional hypermethylation of this gene therefore appears to be an early event in human colorectal neoplasia.
Original languageEnglish
Pages (from-to)429-432
JournalAnticancer Research
Volume17
Publication statusPublished - 1997

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