Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago

Harapan Harapan; Kritu Panta; Alice Michie; Timo Ernst; Suzi McCarthy; Muhsin Muhsin; Safarianti Safarianti; Tjut Mariam Zanaria; Mudatsir Mudatsir; R. Tedjo Sasmono; Allison Imrie

doi:10.3390/v14020219

Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago

Harapan Harapan, Kritu Panta, Alice Michie, Timo Ernst, Suzi McCarthy, Muhsin Muhsin, Safarianti Safarianti, Tjut Mariam Zanaria, Mudatsir Mudatsir, R. Tedjo Sasmono, Allison Imrie

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 randomly sampled healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198/199; 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT₉₀ > 10 and 7 with PRNT₉₀ > 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017.

Original language	English
Article number	219
Journal	Viruses
Volume	14
Issue number	2
DOIs	https://doi.org/10.3390/v14020219
Publication status	Published - Feb 2022

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title = "Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago",

abstract = "The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 randomly sampled healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198/199; 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT90 > 10 and 7 with PRNT90 > 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017.",

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author = "Harapan Harapan and Kritu Panta and Alice Michie and Timo Ernst and Suzi McCarthy and Muhsin Muhsin and Safarianti Safarianti and Zanaria, {Tjut Mariam} and Mudatsir Mudatsir and Sasmono, {R. Tedjo} and Allison Imrie",

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AU - Muhsin, Muhsin

AU - Safarianti, Safarianti

AU - Zanaria, Tjut Mariam

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AU - Sasmono, R. Tedjo

AU - Imrie, Allison

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AB - The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum samples collected from 199 randomly sampled healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198/199; 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT90 > 10 and 7 with PRNT90 > 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017.

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KW - Zika

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Hyperendemic Dengue and Possible Zika Circulation in the Westernmost Region of the Indonesian Archipelago

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