Hydrothermally Synthesized Nickel Oxide Nanosheets for Non-Enzymatic Electrochemical Glucose Detection

A non-enzymatic electrocatalyst, nickel oxide (NiO) nanosheets was developed via a facile hydrothermal approach and further characterized in detail. To harness the potential of NiO nanosheets as a potential electrocatalyst, the hydrothermally synthesized nanosheets were fixed onto the sensor working electrode for glucose sensing application. The NiO nanosheets providing abundance active sites for non-enzymatic glucose detection showed sensitive (1618.4 μA mM^-1 cm^-2) response in the linear range of 0.25-3.75 mM. The excellent electrocatalytic activity of the NiO modified gold working electrode resulted in a low detection limit (2.5 μM). Moreover, the sensor selectively detected glucose in the solution containing common interferants such as cholesterol, dopamine, uric acid and ascorbic acid, further makes it highly suitable for non-enzymatic glucose detection in near-real samples.