Hydration of gelatin molecules studied with terahertz time-domain spectroscopy

S. Fan, Z. Qian, V. P. Wallace

Research output: Chapter in Book/Conference paperConference paper

Abstract

Gelatin is an irreversible hydrolyzed form of collagen having similar amino acid composites with its parent collagen. The hydrogen atoms on the side chains of the long peptide strings can weakly bond with their surrounding gelatin as well as water molecules in aqueous environment, forming a cross-linked 3D matrix. Gelatin has been used as a model for soft tissue phantoms in several medical imaging studies including in terahertz imaging. In the terahertz regime, the dielectric property of the gelatin relies largely on its hydration status and the relationship has been shown to be non-linear. It is therefore essential to study the change of the dielectric properties with respect to the hydration status so as to accurately mimic the properties of fresh biological tissues in the terahertz spectrum. In this work, we studied the hydration status of gelatin with a terahertz time-domain spectroscopy system in the reflection setup. Gelatin gels with different molar weights were prepared with the weight concentration varying from 0 to 33.3%. The complex dielectric constants of the samples were calculated and fitted with an effective medium approximation model. The results provide a quantitative knowledge on the total number of the water molecules affected by each gelatin molecule and how the hydration status is influenced by the concentration and the molar weight.

Original languageEnglish
Title of host publicationInfrared, Millimeter-Wave, and Terahertz Technologies V
EditorsCunlin Zhang, Xi-Cheng Zhang, Masahiko Tani
PublisherSPIE-INT SOC OPTICAL ENGINEERING
Volume10826
ISBN (Electronic)9781510622500
DOIs
Publication statusPublished - 1 Jan 2018
EventInfrared, Millimeter-Wave, and Terahertz Technologies V 2018 - Beijing, China
Duration: 12 Oct 201813 Oct 2018

Conference

ConferenceInfrared, Millimeter-Wave, and Terahertz Technologies V 2018
CountryChina
CityBeijing
Period12/10/1813/10/18

Fingerprint

Hydration
gelatins
Gelatin
hydration
Spectroscopy
Time Domain
Molecules
Dielectric Properties
Collagen
Dielectric properties
spectroscopy
molecules
Terahertz Imaging
Tissue
Water
collagens
Biological Tissue
Hydrogen Atom
Soft Tissue
Dielectric Constant

Cite this

Fan, S., Qian, Z., & Wallace, V. P. (2018). Hydration of gelatin molecules studied with terahertz time-domain spectroscopy. In C. Zhang, X-C. Zhang, & M. Tani (Eds.), Infrared, Millimeter-Wave, and Terahertz Technologies V (Vol. 10826). [1082604] SPIE-INT SOC OPTICAL ENGINEERING. https://doi.org/10.1117/12.2502287
Fan, S. ; Qian, Z. ; Wallace, V. P. / Hydration of gelatin molecules studied with terahertz time-domain spectroscopy. Infrared, Millimeter-Wave, and Terahertz Technologies V. editor / Cunlin Zhang ; Xi-Cheng Zhang ; Masahiko Tani. Vol. 10826 SPIE-INT SOC OPTICAL ENGINEERING, 2018.
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abstract = "Gelatin is an irreversible hydrolyzed form of collagen having similar amino acid composites with its parent collagen. The hydrogen atoms on the side chains of the long peptide strings can weakly bond with their surrounding gelatin as well as water molecules in aqueous environment, forming a cross-linked 3D matrix. Gelatin has been used as a model for soft tissue phantoms in several medical imaging studies including in terahertz imaging. In the terahertz regime, the dielectric property of the gelatin relies largely on its hydration status and the relationship has been shown to be non-linear. It is therefore essential to study the change of the dielectric properties with respect to the hydration status so as to accurately mimic the properties of fresh biological tissues in the terahertz spectrum. In this work, we studied the hydration status of gelatin with a terahertz time-domain spectroscopy system in the reflection setup. Gelatin gels with different molar weights were prepared with the weight concentration varying from 0 to 33.3{\%}. The complex dielectric constants of the samples were calculated and fitted with an effective medium approximation model. The results provide a quantitative knowledge on the total number of the water molecules affected by each gelatin molecule and how the hydration status is influenced by the concentration and the molar weight.",
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Fan, S, Qian, Z & Wallace, VP 2018, Hydration of gelatin molecules studied with terahertz time-domain spectroscopy. in C Zhang, X-C Zhang & M Tani (eds), Infrared, Millimeter-Wave, and Terahertz Technologies V. vol. 10826, 1082604, SPIE-INT SOC OPTICAL ENGINEERING, Infrared, Millimeter-Wave, and Terahertz Technologies V 2018, Beijing, China, 12/10/18. https://doi.org/10.1117/12.2502287

Hydration of gelatin molecules studied with terahertz time-domain spectroscopy. / Fan, S.; Qian, Z.; Wallace, V. P.

Infrared, Millimeter-Wave, and Terahertz Technologies V. ed. / Cunlin Zhang; Xi-Cheng Zhang; Masahiko Tani. Vol. 10826 SPIE-INT SOC OPTICAL ENGINEERING, 2018. 1082604.

Research output: Chapter in Book/Conference paperConference paper

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Fan S, Qian Z, Wallace VP. Hydration of gelatin molecules studied with terahertz time-domain spectroscopy. In Zhang C, Zhang X-C, Tani M, editors, Infrared, Millimeter-Wave, and Terahertz Technologies V. Vol. 10826. SPIE-INT SOC OPTICAL ENGINEERING. 2018. 1082604 https://doi.org/10.1117/12.2502287