TY - JOUR
T1 - Hydration and urinary pseudoephedrine levels after a simulated team game
AU - Jolley, D.
AU - Dawson, Brian
AU - Maloney, Shane
AU - White, J.
AU - Goodman, C.
AU - Peeling, Peter
PY - 2014
Y1 - 2014
N2 - This study investigated the influence of dehydration on urinary levels of pseudoephedrine (PSE) after prolonged repeated effort activity. Fourteen athletes performed a simulated team game circuit (STGC) outdoors over 120 min under three different hydration protocols: hydrated (HYD), dehydrated (DHY) and dehydrated + postexercise fluid bolus (BOL). In all trials, a 60 mg dose of PSE was administered 30 min before trial and at half time of the STGC. Urinary PSE levels were measured before drug administration and at 90 min postexercise. In addition, body mass (BM) changes and urinary specific gravity (USG), osmolality (OSM), creatinine (Cr), and pH values were recorded. No differences in PSE levels were found 90 min postexercise between conditions (HYD: 208.5 ± 116.5; DHY: 238.9 ± 93.5; BOL: 195.6 ± 107.3 μg·ml -1), although large variations were seen within and between participants across conditions (range: 33-475 μg·ml-1: ICC r = .03-0.16, p > .05). There were no differences between conditions in USG, OSM, pH or PSE/Cr ratio. In conclusion, hydration status did not influence urinary PSE levels after prolonged repeated effort activity, with ∼70% of samples greater than the WADA limit (>150 μg·ml-1), and ∼30% under. Due to the unpredictability of urinary PSE values, athletes should avoid taking any medications containing PSE during competition.
AB - This study investigated the influence of dehydration on urinary levels of pseudoephedrine (PSE) after prolonged repeated effort activity. Fourteen athletes performed a simulated team game circuit (STGC) outdoors over 120 min under three different hydration protocols: hydrated (HYD), dehydrated (DHY) and dehydrated + postexercise fluid bolus (BOL). In all trials, a 60 mg dose of PSE was administered 30 min before trial and at half time of the STGC. Urinary PSE levels were measured before drug administration and at 90 min postexercise. In addition, body mass (BM) changes and urinary specific gravity (USG), osmolality (OSM), creatinine (Cr), and pH values were recorded. No differences in PSE levels were found 90 min postexercise between conditions (HYD: 208.5 ± 116.5; DHY: 238.9 ± 93.5; BOL: 195.6 ± 107.3 μg·ml -1), although large variations were seen within and between participants across conditions (range: 33-475 μg·ml-1: ICC r = .03-0.16, p > .05). There were no differences between conditions in USG, OSM, pH or PSE/Cr ratio. In conclusion, hydration status did not influence urinary PSE levels after prolonged repeated effort activity, with ∼70% of samples greater than the WADA limit (>150 μg·ml-1), and ∼30% under. Due to the unpredictability of urinary PSE values, athletes should avoid taking any medications containing PSE during competition.
U2 - 10.1123/ijsnem.2013-0076
DO - 10.1123/ijsnem.2013-0076
M3 - Article
C2 - 24458099
SN - 1526-484X
VL - 24
SP - 325
EP - 332
JO - International Journal of Sport Nutrition and Exercise Metabolism
JF - International Journal of Sport Nutrition and Exercise Metabolism
IS - 3
ER -