Hyaluronic acid in viscous malignant mesothelioma pleural effusion

Hui Min Cheah; Deirdre Fitzgerald; Amber Louw; Jenette Creaney; Y. C.Gary Lee

doi:10.1002/rcr2.694

Hyaluronic acid in viscous malignant mesothelioma pleural effusion

Hui Min Cheah, Deirdre Fitzgerald, Amber Louw, Jenette Creaney, Y. C.Gary Lee

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.

Original language	English
Article number	e00694
Journal	Respirology Case Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1002/rcr2.694
Publication status	Published - Jan 2021

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title = "Hyaluronic acid in viscous malignant mesothelioma pleural effusion",

abstract = "Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.",

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AU - Fitzgerald, Deirdre

AU - Louw, Amber

AU - Creaney, Jenette

AU - Lee, Y. C.Gary

PY - 2021/1

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N2 - Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.

AB - Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity-dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.

KW - Hyaluronic acid

KW - hyaluronidase

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Hyaluronic acid in viscous malignant mesothelioma pleural effusion

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