Human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for the prevention of cervical cancer and HPV-related diseases

Susan Skinner, D. Apter, N. De Carvalho, D. M. M. Harper, R. Konno, J. Paavonen, B. Romanowski, C. Roteli-Martins, N. Burlet, A. Mihalyi, F. Struyf

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26 Citations (Scopus)

Abstract

Vaccines are available against human papillomavirus (HPV), the causal agent of cervical and other cancers. Efficacy data from the HPV-16/18 AS04-adjuvanted vaccine clinical trial program were reviewed. Six randomized, controlled phase II/III trials evaluating cervical endpoints enrolled women from diverse populations and geographical locations. The program analyzed extensively the cohorts most relevant from a public health perspective: the total vaccinated cohort (TVC), approximating a general population including those with existing or previous HPV infection, and TVC-naive, approximating a population of young women before sexual debut. Results show that the vaccine reduces HPV-16/18 infection and associated cervical endpoints in women regardless of age, location, or sexual experience. It provides cross-protection against some non-vaccine oncogenic HPV types and types causing genital warts, and may be effective against vulvar, oral, and anal HPV infection. Early epidemiology data following its introduction suggest a decline in the prevalence of vaccine and some non-vaccine HPV types.
Original languageEnglish
Pages (from-to)367-387
Number of pages21
JournalExpert Review of Vaccines
Volume15
Issue number3
DOIs
Publication statusPublished - 2016

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Skinner, S., Apter, D., De Carvalho, N., Harper, D. M. M., Konno, R., Paavonen, J., ... Struyf, F. (2016). Human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for the prevention of cervical cancer and HPV-related diseases. Expert Review of Vaccines, 15(3), 367-387. https://doi.org/10.1586/14760584.2016.1124763