Human monocytes can produce tissue-type plasminogen activator

P. H. Hart; G. F. Vitti; D. R. Burgess; D. K. Singleton; J. A. Hamilton

doi:10.1084/jem.169.4.1509

Human monocytes can produce tissue-type plasminogen activator

P. H. Hart
, G. F. Vitti
, D. R. Burgess
, D. K. Singleton
, J. A. Hamilton

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Abstract

Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

Original language	English
Pages (from-to)	1509-1514
Number of pages	6
Journal	Journal of Experimental Medicine
Volume	169
Issue number	4
DOIs	https://doi.org/10.1084/jem.169.4.1509
Publication status	Published - 1 Jan 1989
Externally published	Yes

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10.1084/jem.169.4.1509

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title = "Human monocytes can produce tissue-type plasminogen activator",

abstract = "Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.",

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AU - Hart, P. H.

AU - Vitti, G. F.

AU - Burgess, D. R.

AU - Singleton, D. K.

AU - Hamilton, J. A.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

AB - Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

UR - https://www.scopus.com/pages/publications/0024507650

U2 - 10.1084/jem.169.4.1509

DO - 10.1084/jem.169.4.1509

M3 - Article

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SP - 1509

EP - 1514

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 4

ER -

Human monocytes can produce tissue-type plasminogen activator

Abstract

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