Human monocytes can produce tissue-type plasminogen activator

P. H. Hart, G. F. Vitti, D. R. Burgess, D. K. Singleton, J. A. Hamilton

Research output: Contribution to journalArticle

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Abstract

Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

Original languageEnglish
Pages (from-to)1509-1514
Number of pages6
JournalJournal of Experimental Medicine
Volume169
Issue number4
DOIs
Publication statusPublished - 1 Jan 1989
Externally publishedYes

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Tissue Plasminogen Activator
Monocytes
Plasminogen Activators
Urokinase-Type Plasminogen Activator
Macrophages
Messenger RNA

Cite this

Hart, P. H., Vitti, G. F., Burgess, D. R., Singleton, D. K., & Hamilton, J. A. (1989). Human monocytes can produce tissue-type plasminogen activator. Journal of Experimental Medicine, 169(4), 1509-1514. https://doi.org/10.1084/jem.169.4.1509
Hart, P. H. ; Vitti, G. F. ; Burgess, D. R. ; Singleton, D. K. ; Hamilton, J. A. / Human monocytes can produce tissue-type plasminogen activator. In: Journal of Experimental Medicine. 1989 ; Vol. 169, No. 4. pp. 1509-1514.
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Hart, PH, Vitti, GF, Burgess, DR, Singleton, DK & Hamilton, JA 1989, 'Human monocytes can produce tissue-type plasminogen activator' Journal of Experimental Medicine, vol. 169, no. 4, pp. 1509-1514. https://doi.org/10.1084/jem.169.4.1509

Human monocytes can produce tissue-type plasminogen activator. / Hart, P. H.; Vitti, G. F.; Burgess, D. R.; Singleton, D. K.; Hamilton, J. A.

In: Journal of Experimental Medicine, Vol. 169, No. 4, 01.01.1989, p. 1509-1514.

Research output: Contribution to journalArticle

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