Human monocytes can produce tissue-type plasminogen activator

P. H. Hart, G. F. Vitti, D. R. Burgess, D. K. Singleton, J. A. Hamilton

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.

Original languageEnglish
Pages (from-to)1509-1514
Number of pages6
JournalJournal of Experimental Medicine
Issue number4
Publication statusPublished - 1 Jan 1989
Externally publishedYes


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