The dynamic nature of the human mammary gland is evident in its ability to mature and function during pregnancy and lactation. Determining the molecular and cellular drivers of these changes holds the key to understanding normal and abnormal development of the gland. Using mammary cells extracted from human milk, variation of gene expression between participants was determined, as well as genes central to different stages of mammary development. Further analysis revealed genes involved in breast cancer may have a function in normal development where specific neurotrophin receptors are expressed in the gland during lactation. The studies described in this thesis improve the current understanding of the changing landscape of the cellular composition of the mammary gland during pregnancy and lactation.
|Qualification||Doctor of Philosophy|
|Award date||13 Jan 2017|
|Publication status||Unpublished - 2016|