Human milk and allergic diseases: An unsolved puzzle

Daniel Munblit, Diego G. Peroni, Alba Boix-Amorós, Peter S. Hsu, Belinda Van’t Land, Melvin C.L. Gay, Anastasia Kolotilina, Chrysanthi Skevaki, Robert J. Boyle, Maria Carmen Collado, Johan Garssen, Donna T. Geddes, Ralph Nanan, Carolyn Slupsky, Ganesa Wegienka, Anita L. Kozyrskyj, John O. Warner

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.

Original languageEnglish
Article number894
JournalNutrients
Volume9
Issue number8
DOIs
Publication statusPublished - 17 Aug 2017

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Human Milk
breast milk
milk composition
breast feeding
Breast Feeding
milk allergy
Milk Hypersensitivity
oligosaccharides
vitamins
Oligosaccharides
Vitamins
metabolites
nutrients
Food
methodology

Cite this

Munblit, D., Peroni, D. G., Boix-Amorós, A., Hsu, P. S., Van’t Land, B., Gay, M. C. L., ... Warner, J. O. (2017). Human milk and allergic diseases: An unsolved puzzle. Nutrients, 9(8), [894]. https://doi.org/10.3390/nu9080894
Munblit, Daniel ; Peroni, Diego G. ; Boix-Amorós, Alba ; Hsu, Peter S. ; Van’t Land, Belinda ; Gay, Melvin C.L. ; Kolotilina, Anastasia ; Skevaki, Chrysanthi ; Boyle, Robert J. ; Collado, Maria Carmen ; Garssen, Johan ; Geddes, Donna T. ; Nanan, Ralph ; Slupsky, Carolyn ; Wegienka, Ganesa ; Kozyrskyj, Anita L. ; Warner, John O. / Human milk and allergic diseases : An unsolved puzzle. In: Nutrients. 2017 ; Vol. 9, No. 8.
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Munblit, D, Peroni, DG, Boix-Amorós, A, Hsu, PS, Van’t Land, B, Gay, MCL, Kolotilina, A, Skevaki, C, Boyle, RJ, Collado, MC, Garssen, J, Geddes, DT, Nanan, R, Slupsky, C, Wegienka, G, Kozyrskyj, AL & Warner, JO 2017, 'Human milk and allergic diseases: An unsolved puzzle' Nutrients, vol. 9, no. 8, 894. https://doi.org/10.3390/nu9080894

Human milk and allergic diseases : An unsolved puzzle. / Munblit, Daniel; Peroni, Diego G.; Boix-Amorós, Alba; Hsu, Peter S.; Van’t Land, Belinda; Gay, Melvin C.L.; Kolotilina, Anastasia; Skevaki, Chrysanthi; Boyle, Robert J.; Collado, Maria Carmen; Garssen, Johan; Geddes, Donna T.; Nanan, Ralph; Slupsky, Carolyn; Wegienka, Ganesa; Kozyrskyj, Anita L.; Warner, John O.

In: Nutrients, Vol. 9, No. 8, 894, 17.08.2017.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Human milk and allergic diseases

T2 - An unsolved puzzle

AU - Munblit, Daniel

AU - Peroni, Diego G.

AU - Boix-Amorós, Alba

AU - Hsu, Peter S.

AU - Van’t Land, Belinda

AU - Gay, Melvin C.L.

AU - Kolotilina, Anastasia

AU - Skevaki, Chrysanthi

AU - Boyle, Robert J.

AU - Collado, Maria Carmen

AU - Garssen, Johan

AU - Geddes, Donna T.

AU - Nanan, Ralph

AU - Slupsky, Carolyn

AU - Wegienka, Ganesa

AU - Kozyrskyj, Anita L.

AU - Warner, John O.

PY - 2017/8/17

Y1 - 2017/8/17

N2 - There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.

AB - There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.

KW - Allergic diseases

KW - Allergy

KW - Breastfeeding

KW - Cytokines

KW - Human milk

KW - Microbiome

KW - Oligosaccharides

KW - Thymus

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U2 - 10.3390/nu9080894

DO - 10.3390/nu9080894

M3 - Review article

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

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ER -

Munblit D, Peroni DG, Boix-Amorós A, Hsu PS, Van’t Land B, Gay MCL et al. Human milk and allergic diseases: An unsolved puzzle. Nutrients. 2017 Aug 17;9(8). 894. https://doi.org/10.3390/nu9080894