Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HILA-A allelic associations

Jerzy Kulski; A Shigenari; T Shiina; M Ota; K Hosomichi; I James; H Inoko

doi:DOI 10.1534/genetics.108.090340

Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HILA-A allelic associations

Jerzy Kulski, A Shigenari, T Shiina, M Ota, K Hosomichi, I James, H Inoko

Research output: Contribution to journal › Article

Abstract

The frequency and HLA-A allelic associations of a HERVK9 DNA structural polymorphism located in close proximity to the highly polymorphic HLA-A gene within the major histocompatibility complex (MHC) genomic region were determined in Japanese, African Americans, and Australian Caucasians to better understand its human population evolutionary history. The HERVK9 insertion or deletion was detected as a 3' LTR or a solo LTR, respectively, by separate PCR assays. The average insertion frequency of the HERVK9.HG was significantly different (P <1.083e(-6)) between the Japanese (0.59) and the African Americans (0.34) or Australian Caucasians (0.37). LD analysis predicted a highly significant (P

Original language	English
Pages (from-to)	445-457
Journal	Genetics
Volume	180
Issue number	1
DOIs	https://doi.org/DOI 10.1534/genetics.108.090340
Publication status	Published - 2008

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DOI 10.1534/genetics.108.090340

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title = "Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HILA-A allelic associations",

abstract = "The frequency and HLA-A allelic associations of a HERVK9 DNA structural polymorphism located in close proximity to the highly polymorphic HLA-A gene within the major histocompatibility complex (MHC) genomic region were determined in Japanese, African Americans, and Australian Caucasians to better understand its human population evolutionary history. The HERVK9 insertion or deletion was detected as a 3' LTR or a solo LTR, respectively, by separate PCR assays. The average insertion frequency of the HERVK9.HG was significantly different (P <1.083e(-6)) between the Japanese (0.59) and the African Americans (0.34) or Australian Caucasians (0.37). LD analysis predicted a highly significant (P",

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T1 - Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HILA-A allelic associations

AU - Kulski, Jerzy

AU - Shigenari, A

AU - Shiina, T

AU - Ota, M

AU - Hosomichi, K

AU - James, I

AU - Inoko, H

PY - 2008

Y1 - 2008

N2 - The frequency and HLA-A allelic associations of a HERVK9 DNA structural polymorphism located in close proximity to the highly polymorphic HLA-A gene within the major histocompatibility complex (MHC) genomic region were determined in Japanese, African Americans, and Australian Caucasians to better understand its human population evolutionary history. The HERVK9 insertion or deletion was detected as a 3' LTR or a solo LTR, respectively, by separate PCR assays. The average insertion frequency of the HERVK9.HG was significantly different (P <1.083e(-6)) between the Japanese (0.59) and the African Americans (0.34) or Australian Caucasians (0.37). LD analysis predicted a highly significant (P

AB - The frequency and HLA-A allelic associations of a HERVK9 DNA structural polymorphism located in close proximity to the highly polymorphic HLA-A gene within the major histocompatibility complex (MHC) genomic region were determined in Japanese, African Americans, and Australian Caucasians to better understand its human population evolutionary history. The HERVK9 insertion or deletion was detected as a 3' LTR or a solo LTR, respectively, by separate PCR assays. The average insertion frequency of the HERVK9.HG was significantly different (P <1.083e(-6)) between the Japanese (0.59) and the African Americans (0.34) or Australian Caucasians (0.37). LD analysis predicted a highly significant (P

U2 - DOI 10.1534/genetics.108.090340

DO - DOI 10.1534/genetics.108.090340

M3 - Article

VL - 180

SP - 445

EP - 457

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 1

ER -