Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HILA-A allelic associations

Jerzy Kulski, A Shigenari, T Shiina, M Ota, K Hosomichi, I James, H Inoko

    Research output: Contribution to journalArticle

    Abstract

    The frequency and HLA-A allelic associations of a HERVK9 DNA structural polymorphism located in close proximity to the highly polymorphic HLA-A gene within the major histocompatibility complex (MHC) genomic region were determined in Japanese, African Americans, and Australian Caucasians to better understand its human population evolutionary history. The HERVK9 insertion or deletion was detected as a 3' LTR or a solo LTR, respectively, by separate PCR assays. The average insertion frequency of the HERVK9.HG was significantly different (P <1.083e(-6)) between the Japanese (0.59) and the African Americans (0.34) or Australian Caucasians (0.37). LD analysis predicted a highly significant (P
    Original languageEnglish
    Pages (from-to)445-457
    JournalGenetics
    Volume180
    Issue number1
    DOIs
    Publication statusPublished - 2008

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