Human Cytomegalovirus Infection and Cardiovascular Disease: Current Perspectives

Silvia Lee, Jacquita Affandi, Shelley Waters, Patricia Price

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Infections with human cytomegalovirus (HCMV) are often asymptomatic in healthy adults but can be severe in people with a compromised immune system. While several studies have demonstrated associations between cardiovascular disease in older adults and HCMV seropositivity, the underlying mechanisms are unclear. We review evidence published within the last 5 years establishing how HCMV can contribute directly and indirectly to the development and progression of atherosclerotic plaques. We also discuss associations between HCMV infection and cardiovascular outcomes in populations with a high or very high burden of HCMV, including patients with renal or autoimmune disease, transplant recipients, and people living with HIV.
Original languageEnglish
Pages (from-to)13-24
Number of pages12
JournalViral Immunology
Issue number1
Early online date16 Jan 2023
Publication statusPublished - Jan 2023
Externally publishedYes


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