Hormonal predictors of cancer outcomes in the Health In Men Study and Busselton Health Study

Yi Xian Chan

doi:10.26182/3hg5-nd40

Hormonal predictors of cancer outcomes in the Health In Men Study and Busselton Health Study

Yi Xian Chan

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

This thesis explores the associations of circulating thyroid hormones, sex hormones, and IGF1 and its binding proteins, with cancer incidence in two community-based Australian male cohorts. There was a direct association of serum TSH and IGFBP3 with colorectal cancer risk, and of circulating androgens with lung cancer risk in older men. Increased thyroid hormone exposure was associated with prostate cancer risk in middle-aged men. Hormones did not account for the lower prostate cancer risk in older men with diabetes. Further studies are required to explore the utility of hormones as biomarkers for lung, colorectal and prostate cancer risk in men.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Yeap, Bu, Supervisor Fegan, Gerry, Supervisor Flicker, Leon, Supervisor Alfonso, Helman, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	30 Dec 2020
DOIs	https://doi.org/10.26182/3hg5-nd40
Publication status	Unpublished - 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.26182/3hg5-nd40

THESIS - DOCTOR OF PHILOSOPHY - CHAN, Yi Xian - 2020
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Cite this

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title = "Hormonal predictors of cancer outcomes in the Health In Men Study and Busselton Health Study",

abstract = "This thesis explores the associations of circulating thyroid hormones, sex hormones, and IGF1 and its binding proteins, with cancer incidence in two community-based Australian male cohorts. There was a direct association of serum TSH and IGFBP3 with colorectal cancer risk, and of circulating androgens with lung cancer risk in older men. Increased thyroid hormone exposure was associated with prostate cancer risk in middle-aged men. Hormones did not account for the lower prostate cancer risk in older men with diabetes. Further studies are required to explore the utility of hormones as biomarkers for lung, colorectal and prostate cancer risk in men.",

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AB - This thesis explores the associations of circulating thyroid hormones, sex hormones, and IGF1 and its binding proteins, with cancer incidence in two community-based Australian male cohorts. There was a direct association of serum TSH and IGFBP3 with colorectal cancer risk, and of circulating androgens with lung cancer risk in older men. Increased thyroid hormone exposure was associated with prostate cancer risk in middle-aged men. Hormones did not account for the lower prostate cancer risk in older men with diabetes. Further studies are required to explore the utility of hormones as biomarkers for lung, colorectal and prostate cancer risk in men.

KW - Thyroid hormones

KW - IGF1 and its binding proteins

KW - Lung cancer

KW - Sex hormones

KW - Prostate cancer

KW - Colorectal cancer

U2 - 10.26182/3hg5-nd40

DO - 10.26182/3hg5-nd40

M3 - Doctoral Thesis

ER -

Hormonal predictors of cancer outcomes in the Health In Men Study and Busselton Health Study

Abstract

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