Hormonal predictors of cancer outcomes in the Health In Men Study and Busselton Health Study

Yi Xian Chan

Research output: ThesisDoctoral Thesis

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Abstract

This thesis explores the associations of circulating thyroid hormones, sex hormones, and IGF1 and its binding proteins, with cancer incidence in two community-based Australian male cohorts. There was a direct association of serum TSH and IGFBP3 with colorectal cancer risk, and of circulating androgens with lung cancer risk in older men. Increased thyroid hormone exposure was associated with prostate cancer risk in middle-aged men. Hormones did not account for the lower prostate cancer risk in older men with diabetes. Further studies are required to explore the utility of hormones as biomarkers for lung, colorectal and prostate cancer risk in men.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Yeap, Bu, Supervisor
  • Fegan, Gerry, Supervisor
  • Flicker, Leon, Supervisor
  • Alfonso, Helman, Supervisor
Thesis sponsors
Award date30 Dec 2020
DOIs
Publication statusUnpublished - 2020

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