Homocysteine and cardiovascular disease : a 17-year follow-up study in Busselton

Study objective Prospective assessment of serum homocysteine level in relation to risk of coronary heart disease (CHD) and stroke. Design Case-cohort study with 17 years follow up.Methods Homocysteine was measured from stored serum. Proportional hazards regression models were used to obtain adjusted hazard ratios. Results There was no significant overall relationship between homocysteine and cardiovascular disease after controlling for known confounders. For women, removal of creatinine from the multivariate model resulted in a significant relationship. Conclusions These results provide little support for a significant independent relationship between level of homocysteine and risk of CHD or stroke in men and women with no evidence of pre-existing cardiovascular disease.