Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

H.D. Bailey, C. Metayer, Elizabeth Milne, E.T. Petridou, C. Infante-Rivard, L.G. Spector, J. Clavel, J.D. Dockerty, L. Zhang, B.K. Armstrong, J. Rudant, L. Fritschi, A. Amigou, E. Hatzipantelis, A.Y. Kang, E. Stiakaki, J. Schüz

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Abstract

© 2015, Springer International Publishing Switzerland. Purpose: It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL). Methods: We obtained individual level data from eight case–control studies participating in the Childhood Leukemia International Consortium. All studies had home paint exposure data (sometimes including lacquers and varnishes) for the pregnancy period with additional data for the 1–3-month period before conception in five, the year before conception in two, and the period after birth in four studies, respectively. Cytogenetic subtype data were available for some studies. Data were harmonized to a compatible format. Pooled analyses of individual data were undertaken using unconditional logistic regression. Results: Based on 3,002 cases and 3,836 controls, the pooled odds ratio (OR) for home paint exposure in the 1–3 months before conception and risk of ALL was 1.54 [95 % confidence interval (CI) 1.28, 1.85], while based on 1,160 cases and 1,641 controls for exposure in the year before conception, it was 1.00 (95 % CI 0.86, 1.17). For exposure during pregnancy, using 4,382 cases and 5,747 controls, the pooled OR was 1.14 (95 % CI 1.04, 1.25), and for exposure after birth, the OR was 1.22 (95 % CI 1.07, 1.39), based on data from 1,962 cases and 2,973 controls. The risk was greater for certain cytogenetic subtypes and if someone other than the parents did the painting. Conclusions: Home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. It may be prudent to limit exposure during these periods.
Original languageEnglish
Pages (from-to)1257-1270
JournalCancer Causes and Control
Volume26
Issue number9
Early online date2 Jul 2015
DOIs
Publication statusPublished - Sep 2015

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Paint
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Confidence Intervals
Odds Ratio
Parturition
Cytogenetics
Pregnancy
Lacquer
Paintings
Switzerland
Logistic Models

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Bailey, H.D. ; Metayer, C. ; Milne, Elizabeth ; Petridou, E.T. ; Infante-Rivard, C. ; Spector, L.G. ; Clavel, J. ; Dockerty, J.D. ; Zhang, L. ; Armstrong, B.K. ; Rudant, J. ; Fritschi, L. ; Amigou, A. ; Hatzipantelis, E. ; Kang, A.Y. ; Stiakaki, E. ; Schüz, J. / Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium. In: Cancer Causes and Control. 2015 ; Vol. 26, No. 9. pp. 1257-1270.
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title = "Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium",
abstract = "{\circledC} 2015, Springer International Publishing Switzerland. Purpose: It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL). Methods: We obtained individual level data from eight case–control studies participating in the Childhood Leukemia International Consortium. All studies had home paint exposure data (sometimes including lacquers and varnishes) for the pregnancy period with additional data for the 1–3-month period before conception in five, the year before conception in two, and the period after birth in four studies, respectively. Cytogenetic subtype data were available for some studies. Data were harmonized to a compatible format. Pooled analyses of individual data were undertaken using unconditional logistic regression. Results: Based on 3,002 cases and 3,836 controls, the pooled odds ratio (OR) for home paint exposure in the 1–3 months before conception and risk of ALL was 1.54 [95 {\%} confidence interval (CI) 1.28, 1.85], while based on 1,160 cases and 1,641 controls for exposure in the year before conception, it was 1.00 (95 {\%} CI 0.86, 1.17). For exposure during pregnancy, using 4,382 cases and 5,747 controls, the pooled OR was 1.14 (95 {\%} CI 1.04, 1.25), and for exposure after birth, the OR was 1.22 (95 {\%} CI 1.07, 1.39), based on data from 1,962 cases and 2,973 controls. The risk was greater for certain cytogenetic subtypes and if someone other than the parents did the painting. Conclusions: Home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. It may be prudent to limit exposure during these periods.",
author = "H.D. Bailey and C. Metayer and Elizabeth Milne and E.T. Petridou and C. Infante-Rivard and L.G. Spector and J. Clavel and J.D. Dockerty and L. Zhang and B.K. Armstrong and J. Rudant and L. Fritschi and A. Amigou and E. Hatzipantelis and A.Y. Kang and E. Stiakaki and J. Sch{\"u}z",
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Bailey, HD, Metayer, C, Milne, E, Petridou, ET, Infante-Rivard, C, Spector, LG, Clavel, J, Dockerty, JD, Zhang, L, Armstrong, BK, Rudant, J, Fritschi, L, Amigou, A, Hatzipantelis, E, Kang, AY, Stiakaki, E & Schüz, J 2015, 'Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium' Cancer Causes and Control, vol. 26, no. 9, pp. 1257-1270. https://doi.org/10.1007/s10552-015-0618-0

Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium. / Bailey, H.D.; Metayer, C.; Milne, Elizabeth; Petridou, E.T.; Infante-Rivard, C.; Spector, L.G.; Clavel, J.; Dockerty, J.D.; Zhang, L.; Armstrong, B.K.; Rudant, J.; Fritschi, L.; Amigou, A.; Hatzipantelis, E.; Kang, A.Y.; Stiakaki, E.; Schüz, J.

In: Cancer Causes and Control, Vol. 26, No. 9, 09.2015, p. 1257-1270.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

AU - Bailey, H.D.

AU - Metayer, C.

AU - Milne, Elizabeth

AU - Petridou, E.T.

AU - Infante-Rivard, C.

AU - Spector, L.G.

AU - Clavel, J.

AU - Dockerty, J.D.

AU - Zhang, L.

AU - Armstrong, B.K.

AU - Rudant, J.

AU - Fritschi, L.

AU - Amigou, A.

AU - Hatzipantelis, E.

AU - Kang, A.Y.

AU - Stiakaki, E.

AU - Schüz, J.

PY - 2015/9

Y1 - 2015/9

N2 - © 2015, Springer International Publishing Switzerland. Purpose: It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL). Methods: We obtained individual level data from eight case–control studies participating in the Childhood Leukemia International Consortium. All studies had home paint exposure data (sometimes including lacquers and varnishes) for the pregnancy period with additional data for the 1–3-month period before conception in five, the year before conception in two, and the period after birth in four studies, respectively. Cytogenetic subtype data were available for some studies. Data were harmonized to a compatible format. Pooled analyses of individual data were undertaken using unconditional logistic regression. Results: Based on 3,002 cases and 3,836 controls, the pooled odds ratio (OR) for home paint exposure in the 1–3 months before conception and risk of ALL was 1.54 [95 % confidence interval (CI) 1.28, 1.85], while based on 1,160 cases and 1,641 controls for exposure in the year before conception, it was 1.00 (95 % CI 0.86, 1.17). For exposure during pregnancy, using 4,382 cases and 5,747 controls, the pooled OR was 1.14 (95 % CI 1.04, 1.25), and for exposure after birth, the OR was 1.22 (95 % CI 1.07, 1.39), based on data from 1,962 cases and 2,973 controls. The risk was greater for certain cytogenetic subtypes and if someone other than the parents did the painting. Conclusions: Home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. It may be prudent to limit exposure during these periods.

AB - © 2015, Springer International Publishing Switzerland. Purpose: It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL). Methods: We obtained individual level data from eight case–control studies participating in the Childhood Leukemia International Consortium. All studies had home paint exposure data (sometimes including lacquers and varnishes) for the pregnancy period with additional data for the 1–3-month period before conception in five, the year before conception in two, and the period after birth in four studies, respectively. Cytogenetic subtype data were available for some studies. Data were harmonized to a compatible format. Pooled analyses of individual data were undertaken using unconditional logistic regression. Results: Based on 3,002 cases and 3,836 controls, the pooled odds ratio (OR) for home paint exposure in the 1–3 months before conception and risk of ALL was 1.54 [95 % confidence interval (CI) 1.28, 1.85], while based on 1,160 cases and 1,641 controls for exposure in the year before conception, it was 1.00 (95 % CI 0.86, 1.17). For exposure during pregnancy, using 4,382 cases and 5,747 controls, the pooled OR was 1.14 (95 % CI 1.04, 1.25), and for exposure after birth, the OR was 1.22 (95 % CI 1.07, 1.39), based on data from 1,962 cases and 2,973 controls. The risk was greater for certain cytogenetic subtypes and if someone other than the parents did the painting. Conclusions: Home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. It may be prudent to limit exposure during these periods.

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DO - 10.1007/s10552-015-0618-0

M3 - Article

VL - 26

SP - 1257

EP - 1270

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

IS - 9

ER -