TY - JOUR
T1 - HLA-DPB1*0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in Southern Han Chinese
AU - Wang, Honghao
AU - Dai, Yongqiang
AU - Qiu, Wei
AU - Xiaonan, ZHONG
AU - Wu, Aimin
AU - Wang, Yuge
AU - Lu, Zhengqi
AU - Bao, Jian
AU - Hu, Xueqiang
N1 - Funding Information:
The authors wish to thank Huada Gene (Shenzhen) for helping us on HLA-typing. This study was supported by the Sun Yat-sen University Clinical Research 5010 Program (grant number 2007027 ) and the Technology Project of Guangzhou City (No. 2060402 ).
PY - 2011/4
Y1 - 2011/4
N2 - Objectives: To analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese. Methods: Thirty serum anti-aquaporin 4 antibodies (AQP4-Ab)-positive NMO patients, 53 conventional multiple sclerosis (C-MS) patients, and 93 controls (CTLs) were enrolled. The HLA-DRB1 and -DPB1 alleles of the subjects were determined by sequencing-based typing (SBT). Results: The frequency of the DRB1*0901 was lower in NMO patients than in CTLs (Puncorr=0.022, OR: 0.194, 95% CI: 0.043-0.876), and DRB1*1602 was higher in NMO patients than in C-MS (Puncorr=0.038, OR: 3.491, 95% CI: 1.024-11.896) and CTLs (Puncorr=0.051, OR: 2.711, 95% CI: 0.971-7.556). The frequency of DPB1*0501 was significant higher in NMO patients than in C-MS (Puncorr=0.018, OR: 4.629, 95% CI: 1.235-17.350) and CTLs (Puncorr=0.001, Pcorr=0.022, OR: 7.096, 95% CI: 2.011-25.044). Conclusions: DPB1*0501 correlates with risk of AQP4-Ab positive NMO in Southern Han Chinese.
AB - Objectives: To analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese. Methods: Thirty serum anti-aquaporin 4 antibodies (AQP4-Ab)-positive NMO patients, 53 conventional multiple sclerosis (C-MS) patients, and 93 controls (CTLs) were enrolled. The HLA-DRB1 and -DPB1 alleles of the subjects were determined by sequencing-based typing (SBT). Results: The frequency of the DRB1*0901 was lower in NMO patients than in CTLs (Puncorr=0.022, OR: 0.194, 95% CI: 0.043-0.876), and DRB1*1602 was higher in NMO patients than in C-MS (Puncorr=0.038, OR: 3.491, 95% CI: 1.024-11.896) and CTLs (Puncorr=0.051, OR: 2.711, 95% CI: 0.971-7.556). The frequency of DPB1*0501 was significant higher in NMO patients than in C-MS (Puncorr=0.018, OR: 4.629, 95% CI: 1.235-17.350) and CTLs (Puncorr=0.001, Pcorr=0.022, OR: 7.096, 95% CI: 2.011-25.044). Conclusions: DPB1*0501 correlates with risk of AQP4-Ab positive NMO in Southern Han Chinese.
KW - HLA-DRB1
KW - Multiple sclerosis
KW - Neuromyelitis optica
UR - http://www.scopus.com/inward/record.url?scp=79953320825&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2010.11.004
DO - 10.1016/j.jneuroim.2010.11.004
M3 - Article
C2 - 21130504
SN - 0165-5728
VL - 233
SP - 181
EP - 184
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -