HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates

Jerzy K. Kulski, Habiba S. AlSafar, Aurelie Mawart, Andreas Henschel, Guan K. Tay

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of three HLA class I loci at HLA-A, -B and -C for 95 unrelated healthy Bedouins from the cities of Al Ain and Abu Dhabi in the UAE. A total of 54 HLA allele lineages were detected; the most frequent low-resolution allele lineages at each HLA locus were A*02 (0.268), B*51 (0.163) and C*07 (0.216). The inferred estimates for the two most frequent HLA-A and HLA-B haplotypes were HLA-A*02 similar to HLA-B*50 (0.070) and HLA-A*02 similar to HLA-B*51 (0.051), and the most frequent 3-locus haplotype was HLA-A*02 similar to HLA-B*50 similar to HLA-C*06 (0.068). The HLA allele lineage frequencies of the UAE Arabs were compared to those previously reported for 70 other world populations, and a strong genetic similarity was detected between the UAE Arabs and the Saudi Arabians from the west with evidence of a limited gene flow between the UAE Arabs and Pakistani across the Gulf from the east, and the UAE Arabs and Omani from the south of the Gulf Peninsula.

Original languageEnglish
Pages (from-to)152-159
Number of pages8
JournalInternational Journal of Immunogenetics
Volume46
Issue number3
DOIs
Publication statusPublished - Jun 2019

Cite this

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title = "HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates",
abstract = "The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of three HLA class I loci at HLA-A, -B and -C for 95 unrelated healthy Bedouins from the cities of Al Ain and Abu Dhabi in the UAE. A total of 54 HLA allele lineages were detected; the most frequent low-resolution allele lineages at each HLA locus were A*02 (0.268), B*51 (0.163) and C*07 (0.216). The inferred estimates for the two most frequent HLA-A and HLA-B haplotypes were HLA-A*02 similar to HLA-B*50 (0.070) and HLA-A*02 similar to HLA-B*51 (0.051), and the most frequent 3-locus haplotype was HLA-A*02 similar to HLA-B*50 similar to HLA-C*06 (0.068). The HLA allele lineage frequencies of the UAE Arabs were compared to those previously reported for 70 other world populations, and a strong genetic similarity was detected between the UAE Arabs and the Saudi Arabians from the west with evidence of a limited gene flow between the UAE Arabs and Pakistani across the Gulf from the east, and the UAE Arabs and Omani from the south of the Gulf Peninsula.",
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HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates. / Kulski, Jerzy K.; AlSafar, Habiba S.; Mawart, Aurelie; Henschel, Andreas; Tay, Guan K.

In: International Journal of Immunogenetics, Vol. 46, No. 3, 06.2019, p. 152-159.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates

AU - Kulski, Jerzy K.

AU - AlSafar, Habiba S.

AU - Mawart, Aurelie

AU - Henschel, Andreas

AU - Tay, Guan K.

PY - 2019/6

Y1 - 2019/6

N2 - The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of three HLA class I loci at HLA-A, -B and -C for 95 unrelated healthy Bedouins from the cities of Al Ain and Abu Dhabi in the UAE. A total of 54 HLA allele lineages were detected; the most frequent low-resolution allele lineages at each HLA locus were A*02 (0.268), B*51 (0.163) and C*07 (0.216). The inferred estimates for the two most frequent HLA-A and HLA-B haplotypes were HLA-A*02 similar to HLA-B*50 (0.070) and HLA-A*02 similar to HLA-B*51 (0.051), and the most frequent 3-locus haplotype was HLA-A*02 similar to HLA-B*50 similar to HLA-C*06 (0.068). The HLA allele lineage frequencies of the UAE Arabs were compared to those previously reported for 70 other world populations, and a strong genetic similarity was detected between the UAE Arabs and the Saudi Arabians from the west with evidence of a limited gene flow between the UAE Arabs and Pakistani across the Gulf from the east, and the UAE Arabs and Omani from the south of the Gulf Peninsula.

AB - The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of three HLA class I loci at HLA-A, -B and -C for 95 unrelated healthy Bedouins from the cities of Al Ain and Abu Dhabi in the UAE. A total of 54 HLA allele lineages were detected; the most frequent low-resolution allele lineages at each HLA locus were A*02 (0.268), B*51 (0.163) and C*07 (0.216). The inferred estimates for the two most frequent HLA-A and HLA-B haplotypes were HLA-A*02 similar to HLA-B*50 (0.070) and HLA-A*02 similar to HLA-B*51 (0.051), and the most frequent 3-locus haplotype was HLA-A*02 similar to HLA-B*50 similar to HLA-C*06 (0.068). The HLA allele lineage frequencies of the UAE Arabs were compared to those previously reported for 70 other world populations, and a strong genetic similarity was detected between the UAE Arabs and the Saudi Arabians from the west with evidence of a limited gene flow between the UAE Arabs and Pakistani across the Gulf from the east, and the UAE Arabs and Omani from the south of the Gulf Peninsula.

KW - alleles frequencies

KW - Arabian population

KW - haplotype frequencies

KW - HLA-A

KW - HLA-B

KW - HLA-C

KW - MHC class I

KW - middle East

KW - phylogenetic tree

KW - population genetics

KW - BEHCETS-DISEASE

KW - POPULATION

KW - SOFTWARE

KW - DISEQUILIBRIUM

KW - DATABASE

KW - UPDATE

KW - LOCI

U2 - 10.1111/iji.12418

DO - 10.1111/iji.12418

M3 - Article

VL - 46

SP - 152

EP - 159

JO - European Journal of Immunogenetics

JF - European Journal of Immunogenetics

SN - 0960-7420

IS - 3

ER -