HLA and immunodominance in viral infection: T-cell responses in protection and immunopathogenesis

Allison Imrie, Suzi McCarthy

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The protective role of T cells in viral infection is well described. T cells generally mediate anti-viral immune responses via direct cytotoxicity and production of pro-inflammatory cytokines, by providing help to B cells and by promotion of memory responses. A fundamental step in T cell responses involves presentation of viral peptide antigens in the context of human leucocyte antigens (HLA), to the T-cell receptor. HLA are highly polymorphic cell surface molecules that present a vast array of peptides to T cells and induce their activation, differentiation and proliferation into effector cells which can eliminate microbial infection.

Original languageEnglish
Pages (from-to)84-86
Number of pages3
JournalMicrobiology Australia
Volume42
Issue number2
DOIs
Publication statusPublished - Jun 2021

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