HIV infection as risk factor for death among hospitalized persons with Candidemia, South Africa, 2012-2017

GERMS-SA

doi:10.3201/eid2706.210128

HIV infection as risk factor for death among hospitalized persons with Candidemia, South Africa, 2012-2017

GERMS-SA

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.

Original language	English
Pages (from-to)	1607-1615
Number of pages	9
Journal	Emerging Infectious Diseases
Volume	27
Issue number	6
DOIs	https://doi.org/10.3201/eid2706.210128
Publication status	Published - Jun 2021

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10.3201/eid2706.210128

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@article{ff37437c22614b658fd8170ad9519c7d,

title = "HIV infection as risk factor for death among hospitalized persons with Candidemia, South Africa, 2012-2017",

abstract = "We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.",

author = "GERMS-SA and Govender, {Nelesh P.} and Jim Todd and Jeremy Nel and Mervyn Mer and Alan Karstaedt and Cheryl Cohen and Mark Nicol and Adrian Brink and Ebrahim Hoosien and Elizabeth Prentice and Inge Zietsman and Maria Botha and Peter Smith and Terry Marshall and Xoliswa Poswa and Chetna Govind and Juanita Smit and Keshree Pillay and Sharona Seetharam and Suzy Budavari and Victoria Howell and Carel Haumann and Catherine Samuel and Marthinus Senekal and Andries Dreyer and Khatija Ahmed and Louis Marcus and Warren Lowman and Angeliki Messina and {van den Bergh}, Dena and Karin Swart and Ananta Nanoo and Andries Dreyer and {von Gottberg}, Anne and Arvinda Sooka and Cecilia Miller and Charlotte Sriruttan and Chikwe Ihekweazu and {von Mollendorf}, Claire and {du Plessis}, Desiree and {van Schalkwyk}, Erika and Farzana Ismail and Frans Radebe and Genevie Ntshoe and Gillian Hunt and Hlengani Mathema and Husna Ismail and Jacqueline Weyer and Jackie Kleynhans and Jenny Rossouw and John Frean and Joy Ebonwu and Judith Mwansa-Kambafwile and Karen Keddy and Kerrigan McCarthy and Liliwe Shuping and {de Gouveia}, Linda and Linda Erasmus and Lucille Blumberg and Marshagne Smith and Martha Makgoba and Motshabi Modise and Nazir Ismail and Nelesh Govender and Neo Legare and Nicola Page and Ntsieni Ramalwa and Nuraan Paulse and Phumeza Vazi and Olga Perovic and Penny Crowther-Gibson and Portia Mutevedzi and Riyadh Manesen and Ranmini Kularatne and Ruth Mpembe and Sarona Lengana and Shabir Madhi and Omar, {Shaheed Vally} and Sibongile Walaza and Sonwabo Lindani and Sunnieboy Njikho and Susan Meiring and Thejane Motladiile and Tiisetso Lebaka and Vanessa Quan and Verushka Chetty and Serisha Naicker and Tsidiso Maphanga and Mabatho Mhlanga and Zulu, {Thokozile Gloria} and Ernest Tsotetsi and Phelly Matlapeng and Siphiwe Kutta and Lerato Qoza and Sydney Mogokotleng and Mbali Dube and Amanda Shilubane",

year = "2021",

month = jun,

doi = "10.3201/eid2706.210128",

language = "English",

volume = "27",

pages = "1607--1615",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention",

number = "6",

}

TY - JOUR

T1 - HIV infection as risk factor for death among hospitalized persons with Candidemia, South Africa, 2012-2017

AU - GERMS-SA

AU - Govender, Nelesh P.

AU - Todd, Jim

AU - Nel, Jeremy

AU - Mer, Mervyn

AU - Karstaedt, Alan

AU - Cohen, Cheryl

AU - Nicol, Mark

AU - Brink, Adrian

AU - Hoosien, Ebrahim

AU - Prentice, Elizabeth

AU - Zietsman, Inge

AU - Botha, Maria

AU - Smith, Peter

AU - Marshall, Terry

AU - Poswa, Xoliswa

AU - Govind, Chetna

AU - Smit, Juanita

AU - Pillay, Keshree

AU - Seetharam, Sharona

AU - Budavari, Suzy

AU - Howell, Victoria

AU - Haumann, Carel

AU - Samuel, Catherine

AU - Senekal, Marthinus

AU - Dreyer, Andries

AU - Ahmed, Khatija

AU - Marcus, Louis

AU - Lowman, Warren

AU - Messina, Angeliki

AU - van den Bergh, Dena

AU - Swart, Karin

AU - Nanoo, Ananta

AU - Dreyer, Andries

AU - von Gottberg, Anne

AU - Sooka, Arvinda

AU - Miller, Cecilia

AU - Sriruttan, Charlotte

AU - Ihekweazu, Chikwe

AU - von Mollendorf, Claire

AU - du Plessis, Desiree

AU - van Schalkwyk, Erika

AU - Ismail, Farzana

AU - Radebe, Frans

AU - Ntshoe, Genevie

AU - Hunt, Gillian

AU - Mathema, Hlengani

AU - Ismail, Husna

AU - Weyer, Jacqueline

AU - Kleynhans, Jackie

AU - Rossouw, Jenny

AU - Frean, John

AU - Ebonwu, Joy

AU - Mwansa-Kambafwile, Judith

AU - Keddy, Karen

AU - McCarthy, Kerrigan

AU - Shuping, Liliwe

AU - de Gouveia, Linda

AU - Erasmus, Linda

AU - Blumberg, Lucille

AU - Smith, Marshagne

AU - Makgoba, Martha

AU - Modise, Motshabi

AU - Ismail, Nazir

AU - Govender, Nelesh

AU - Legare, Neo

AU - Page, Nicola

AU - Ramalwa, Ntsieni

AU - Paulse, Nuraan

AU - Vazi, Phumeza

AU - Perovic, Olga

AU - Crowther-Gibson, Penny

AU - Mutevedzi, Portia

AU - Manesen, Riyadh

AU - Kularatne, Ranmini

AU - Mpembe, Ruth

AU - Lengana, Sarona

AU - Madhi, Shabir

AU - Omar, Shaheed Vally

AU - Walaza, Sibongile

AU - Lindani, Sonwabo

AU - Njikho, Sunnieboy

AU - Meiring, Susan

AU - Motladiile, Thejane

AU - Lebaka, Tiisetso

AU - Quan, Vanessa

AU - Chetty, Verushka

AU - Naicker, Serisha

AU - Maphanga, Tsidiso

AU - Mhlanga, Mabatho

AU - Zulu, Thokozile Gloria

AU - Tsotetsi, Ernest

AU - Matlapeng, Phelly

AU - Kutta, Siphiwe

AU - Qoza, Lerato

AU - Mogokotleng, Sydney

AU - Dube, Mbali

AU - Shilubane, Amanda

PY - 2021/6

Y1 - 2021/6

N2 - We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.

AB - We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012-2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50-2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38-2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47-3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00-2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care.

UR - http://www.scopus.com/inward/record.url?scp=85106496116&partnerID=8YFLogxK

U2 - 10.3201/eid2706.210128

DO - 10.3201/eid2706.210128

M3 - Review article

C2 - 34014153

AN - SCOPUS:85106496116

SN - 1080-6040

VL - 27

SP - 1607

EP - 1615

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 6

ER -

HIV infection as risk factor for death among hospitalized persons with Candidemia, South Africa, 2012-2017

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