Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis

Daniel Lobato Ferreira Ferraz; Erison Santana Dos Santos; Caique Mariano Pedroso; Brunno Santos de Freitas Silva; Omar Kujan; Tuula Anneli Salo; Mohammed I Malki; Susanna Juteau; Pablo Agustin Vargas; Marcio Ajudarte Lopes; Alan Roger Santos-Silva

doi:10.1111/odi.15052

Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis

Daniel Lobato Ferreira Ferraz, Erison Santana Dos Santos, Caique Mariano Pedroso, Brunno Santos de Freitas Silva, Omar Kujan, Tuula Anneli Salo, Mohammed I Malki, Susanna Juteau, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva

Oral Diagnostic and Surgical Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

OBJECTIVE: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.

METHODS: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.

RESULTS: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.

CONCLUSIONS: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

Original language	English
Journal	Oral Diseases
DOIs	https://doi.org/10.1111/odi.15052
Publication status	E-pub ahead of print - 30 Jun 2024

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@article{18b7f9d389434fefba960d5d48941759,

title = "Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis",

abstract = "OBJECTIVE: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.METHODS: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.RESULTS: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.CONCLUSIONS: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.",

author = "Ferraz, {Daniel Lobato Ferreira} and {Dos Santos}, {Erison Santana} and Pedroso, {Caique Mariano} and Silva, {Brunno Santos de Freitas} and Omar Kujan and Salo, {Tuula Anneli} and Malki, {Mohammed I} and Susanna Juteau and Vargas, {Pablo Agustin} and Lopes, {Marcio Ajudarte} and Santos-Silva, {Alan Roger}",

note = "{\textcopyright} 2024 Wiley Periodicals LLC.",

year = "2024",

month = jun,

day = "30",

doi = "10.1111/odi.15052",

language = "English",

journal = "Oral Diseases",

issn = "1354-523X",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Histopathological risk assessment in multisite epithelial dysplasia

T2 - A meta-analysis

AU - Ferraz, Daniel Lobato Ferreira

AU - Dos Santos, Erison Santana

AU - Pedroso, Caique Mariano

AU - Silva, Brunno Santos de Freitas

AU - Kujan, Omar

AU - Salo, Tuula Anneli

AU - Malki, Mohammed I

AU - Juteau, Susanna

AU - Vargas, Pablo Agustin

AU - Lopes, Marcio Ajudarte

AU - Santos-Silva, Alan Roger

PY - 2024/6/30

Y1 - 2024/6/30

N2 - OBJECTIVE: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.METHODS: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.RESULTS: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.CONCLUSIONS: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

AB - OBJECTIVE: Histopathological grading of oral epithelial dysplasia (OED) is the current standard for stratifying cancer progression risk but is associated with subjectivity and variability. This problem is not commonly seen regarding the grading of epithelial dysplasia in other sites. This systematic review aims to compare grading systems for oral, anal, penile, and cervical epithelial dysplasia to determine their predictive accuracy for recurrence and malignant transformation (MT) outcomes.METHODS: The review protocol was registered in PROSPERO (CRD42023403035) and was reported according to the PRISMA checklist. A comprehensive search was performed in the main databases and gray literature. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist for each study design.RESULTS: Forty-six studies were deemed eligible and included in this systematic review, of which 45 were included in the quantitative analysis. Meta-analysis revealed that the binary system demonstrated a higher predictive ability for MT/recurrence of OED compared to multilevel systems. Higher predictive accuracy of MT was also observed for binary grading systems in anal intraepithelial neoplasia.CONCLUSIONS: No significant difference was found between the current grading systems of epithelial dysplasia in different body parts. However, binary grading systems have shown better clinical outcomes.

U2 - 10.1111/odi.15052

DO - 10.1111/odi.15052

M3 - Review article

C2 - 38946217

SN - 1354-523X

JO - Oral Diseases

JF - Oral Diseases

ER -

Histopathological risk assessment in multisite epithelial dysplasia: A meta-analysis

Abstract

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