Histological chorioamnionitis and developmental outcomes in very preterm infants

Research output: Contribution to journalArticle

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Abstract

Objective To characterize the association of histological chorioamnionitis (HCA) with neurodevelopmental outcomes in children born at

Study design This retrospective cohort study included infants born 2006-2012 in whom placental histopathology, neonatal outcomes, and Bayley-III assessment at age 2 years were available. We assessed the association of HCA exposure with cognitive, language, and motor delay with logistic regression models adjusted for gestational age, sex, small for gestational age and brain injury.

Results Of 1353 infants, 985 had histological and neonatal data available, and 708 infants had Bayley-III assessments. HCA-exposed infants were at higher risk of some neonatal adverse outcomes, and stage of HCA correlated with low Apgar score and early-onset sepsis. Exposure to HCA was not associated with neurodevelopmental outcomes in adjusted models including stage of HCA.

Conclusions Exposure to HCA, especially higher stage, was associated with neonatal morbidity but not with adverse neurodevelopmental outcomes at 2 years of age.

Original languageEnglish
Pages (from-to)321-330
Number of pages10
JournalJournal of Perinatology
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2019

Cite this

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title = "Histological chorioamnionitis and developmental outcomes in very preterm infants",
abstract = "Objective To characterize the association of histological chorioamnionitis (HCA) with neurodevelopmental outcomes in children born atStudy design This retrospective cohort study included infants born 2006-2012 in whom placental histopathology, neonatal outcomes, and Bayley-III assessment at age 2 years were available. We assessed the association of HCA exposure with cognitive, language, and motor delay with logistic regression models adjusted for gestational age, sex, small for gestational age and brain injury.Results Of 1353 infants, 985 had histological and neonatal data available, and 708 infants had Bayley-III assessments. HCA-exposed infants were at higher risk of some neonatal adverse outcomes, and stage of HCA correlated with low Apgar score and early-onset sepsis. Exposure to HCA was not associated with neurodevelopmental outcomes in adjusted models including stage of HCA.Conclusions Exposure to HCA, especially higher stage, was associated with neonatal morbidity but not with adverse neurodevelopmental outcomes at 2 years of age.",
keywords = "LOW-BIRTH-WEIGHT, 1ST POSTNATAL MONTH, SYSTEMIC INFLAMMATION, CEREBRAL-PALSY, NEURODEVELOPMENTAL OUTCOMES, CHILDREN BORN, BAYLEY SCALES, RISK, ASSOCIATION, CONSENSUS",
author = "Tobias Strunk and Catherine Campbell and David Burgner and Adrian Charles and Noel French and Mary Sharp and Karen Simmer and Elizabeth Nathan and Dorota Doherty",
year = "2019",
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doi = "10.1038/s41372-018-0288-3",
language = "English",
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pages = "321--330",
journal = "Journal of Perinatology",
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Histological chorioamnionitis and developmental outcomes in very preterm infants. / Strunk, Tobias; Campbell, Catherine; Burgner, David; Charles, Adrian; French, Noel; Sharp, Mary; Simmer, Karen; Nathan, Elizabeth; Doherty, Dorota.

In: Journal of Perinatology, Vol. 39, No. 2, 02.2019, p. 321-330.

Research output: Contribution to journalArticle

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T1 - Histological chorioamnionitis and developmental outcomes in very preterm infants

AU - Strunk, Tobias

AU - Campbell, Catherine

AU - Burgner, David

AU - Charles, Adrian

AU - French, Noel

AU - Sharp, Mary

AU - Simmer, Karen

AU - Nathan, Elizabeth

AU - Doherty, Dorota

PY - 2019/2

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N2 - Objective To characterize the association of histological chorioamnionitis (HCA) with neurodevelopmental outcomes in children born atStudy design This retrospective cohort study included infants born 2006-2012 in whom placental histopathology, neonatal outcomes, and Bayley-III assessment at age 2 years were available. We assessed the association of HCA exposure with cognitive, language, and motor delay with logistic regression models adjusted for gestational age, sex, small for gestational age and brain injury.Results Of 1353 infants, 985 had histological and neonatal data available, and 708 infants had Bayley-III assessments. HCA-exposed infants were at higher risk of some neonatal adverse outcomes, and stage of HCA correlated with low Apgar score and early-onset sepsis. Exposure to HCA was not associated with neurodevelopmental outcomes in adjusted models including stage of HCA.Conclusions Exposure to HCA, especially higher stage, was associated with neonatal morbidity but not with adverse neurodevelopmental outcomes at 2 years of age.

AB - Objective To characterize the association of histological chorioamnionitis (HCA) with neurodevelopmental outcomes in children born atStudy design This retrospective cohort study included infants born 2006-2012 in whom placental histopathology, neonatal outcomes, and Bayley-III assessment at age 2 years were available. We assessed the association of HCA exposure with cognitive, language, and motor delay with logistic regression models adjusted for gestational age, sex, small for gestational age and brain injury.Results Of 1353 infants, 985 had histological and neonatal data available, and 708 infants had Bayley-III assessments. HCA-exposed infants were at higher risk of some neonatal adverse outcomes, and stage of HCA correlated with low Apgar score and early-onset sepsis. Exposure to HCA was not associated with neurodevelopmental outcomes in adjusted models including stage of HCA.Conclusions Exposure to HCA, especially higher stage, was associated with neonatal morbidity but not with adverse neurodevelopmental outcomes at 2 years of age.

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