TY - JOUR
T1 - Histocompatibility Matching for Bone Marrow Transplantation
T2 - Donor/Recipient Pairs in the 4AOHW Cell Panel
AU - Christiansen, FT
AU - Tay, G
AU - Smith, LK
AU - Witt, CS
AU - Petersdorf, EW
AU - Bradley, B
AU - Dawkins, RL
PY - 1993
Y1 - 1993
N2 - While the results of unrelated bone marrow transplantation are continually improving, a number of important issues remain: what are the histocompatibility requirements, what genes are involved, what mismatches are acceptable, and what are the best methods for determining donor-recipient match? In this study of material provided through the 4AOHW and the US NMDP, the match between 53 donor-recipient pairs was determined using several different markers within the MHC. The data showed that many apparently well-matched pairs have many mismatches, including mismatches for non-HLA genes (i.e., non-class-I or non-class-II) within the MHC. New methods matching for blocks of DNA around HLA-B and around HLA-DR/DQ are available that are sensitive and identify additional mismatches that are not apparent using conventional typing methods. The 4AOHW cells provide a valuable resource for the comparison and assessment of new matching techniques.
AB - While the results of unrelated bone marrow transplantation are continually improving, a number of important issues remain: what are the histocompatibility requirements, what genes are involved, what mismatches are acceptable, and what are the best methods for determining donor-recipient match? In this study of material provided through the 4AOHW and the US NMDP, the match between 53 donor-recipient pairs was determined using several different markers within the MHC. The data showed that many apparently well-matched pairs have many mismatches, including mismatches for non-HLA genes (i.e., non-class-I or non-class-II) within the MHC. New methods matching for blocks of DNA around HLA-B and around HLA-DR/DQ are available that are sensitive and identify additional mismatches that are not apparent using conventional typing methods. The 4AOHW cells provide a valuable resource for the comparison and assessment of new matching techniques.
UR - http://europepmc.org/abstract/med/8307786
U2 - 10.1016/0198-8859(93)90518-6
DO - 10.1016/0198-8859(93)90518-6
M3 - Article
C2 - 8307786
VL - 38
SP - 42
EP - 51
JO - Human Immunology
JF - Human Immunology
ER -