Histamine induces opposing vasoactive effects at different levels of the ocular vasculature

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Abstract

Purpose: To characterize the vasoactive properties and receptors of histamine in porcine retinal arterioles compared to that in the long posterior ciliary artery. Methods: Isolated perfused porcine retinal arterioles were used to study vessel diameter in response to histamine (10(-10) to 10(-4) M). Ring segments from the long posterior ciliary artery were used to study contractile force in response to histamine. Results: Histamine-induced vasodilatation in pig retinal arterioles but contraction in the long posterior ciliary artery. In retinal arterioles, the involvement of H-2 receptors was implied by the attenuation of the histamine response in the presence of cimetidine. Further attenuation of the histamine response by pyrilamine suggests the involvement of H-1 receptors. In retinal arterioles denuded of endothelial cells, the histamine response was only slightly reduced. Conclusion: Histamine induces opposing vasoactive effects at different levels of the porcine ocular vasculature.
Original languageEnglish
Pages (from-to)205-212
JournalCurrent Eye Research
Volume30
Issue number3
DOIs
Publication statusPublished - 2005

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