Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: Type 2 diabetes mellitus is associated with global and hippocampal atrophy and cognitive deficits, and some studies suggest that the right hippocampus may display greater vulnerability than the left. Methods: Hippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes. Results: The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. These associations were stronger with the hippocampal asymmetry index and remained significant for memory and executive function after additional adjustment for global brain atrophy. Conclusions: We conclude that asymmetric hippocampal atrophy may occur in type 2 diabetes, with greater atrophy occurring in the right than the left hippocampus, and that this may contribute to cognitive impairment in this disorder. These cross-sectional associations require further verification but may provide clues into the pathogenesis of cognitive disorders in type 2 diabetes.

Original languageEnglish
Article numbere00741
JournalBrain and Behavior
Volume8
Issue number1
DOIs
Publication statusPublished - 2018

Fingerprint

Type 2 Diabetes Mellitus
Cognition
Atrophy
Executive Function
Hippocampus
Semantics
Brain

Cite this

@article{02a0996b78854205a38c6736e2372a91,
title = "Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus",
abstract = "Introduction: Type 2 diabetes mellitus is associated with global and hippocampal atrophy and cognitive deficits, and some studies suggest that the right hippocampus may display greater vulnerability than the left. Methods: Hippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes. Results: The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. These associations were stronger with the hippocampal asymmetry index and remained significant for memory and executive function after additional adjustment for global brain atrophy. Conclusions: We conclude that asymmetric hippocampal atrophy may occur in type 2 diabetes, with greater atrophy occurring in the right than the left hippocampus, and that this may contribute to cognitive impairment in this disorder. These cross-sectional associations require further verification but may provide clues into the pathogenesis of cognitive disorders in type 2 diabetes.",
keywords = "Cognition, Hippocampus, Magnetic resonance imaging, Type 2 diabetes",
author = "Milne, {Nicole T.} and Bucks, {Romola S.} and Davis, {Wendy A.} and Davis, {Timothy M.E.} and Ronald Pierson and Starkstein, {Sergio E.} and Bruce, {David G.}",
year = "2018",
doi = "10.1002/brb3.741",
language = "English",
volume = "8",
journal = "Brain and Behavior",
issn = "2162-3279",
publisher = "John Wiley & Sons",
number = "1",

}

TY - JOUR

T1 - Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus

AU - Milne, Nicole T.

AU - Bucks, Romola S.

AU - Davis, Wendy A.

AU - Davis, Timothy M.E.

AU - Pierson, Ronald

AU - Starkstein, Sergio E.

AU - Bruce, David G.

PY - 2018

Y1 - 2018

N2 - Introduction: Type 2 diabetes mellitus is associated with global and hippocampal atrophy and cognitive deficits, and some studies suggest that the right hippocampus may display greater vulnerability than the left. Methods: Hippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes. Results: The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. These associations were stronger with the hippocampal asymmetry index and remained significant for memory and executive function after additional adjustment for global brain atrophy. Conclusions: We conclude that asymmetric hippocampal atrophy may occur in type 2 diabetes, with greater atrophy occurring in the right than the left hippocampus, and that this may contribute to cognitive impairment in this disorder. These cross-sectional associations require further verification but may provide clues into the pathogenesis of cognitive disorders in type 2 diabetes.

AB - Introduction: Type 2 diabetes mellitus is associated with global and hippocampal atrophy and cognitive deficits, and some studies suggest that the right hippocampus may display greater vulnerability than the left. Methods: Hippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes. Results: The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. These associations were stronger with the hippocampal asymmetry index and remained significant for memory and executive function after additional adjustment for global brain atrophy. Conclusions: We conclude that asymmetric hippocampal atrophy may occur in type 2 diabetes, with greater atrophy occurring in the right than the left hippocampus, and that this may contribute to cognitive impairment in this disorder. These cross-sectional associations require further verification but may provide clues into the pathogenesis of cognitive disorders in type 2 diabetes.

KW - Cognition

KW - Hippocampus

KW - Magnetic resonance imaging

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85038814235&partnerID=8YFLogxK

U2 - 10.1002/brb3.741

DO - 10.1002/brb3.741

M3 - Article

VL - 8

JO - Brain and Behavior

JF - Brain and Behavior

SN - 2162-3279

IS - 1

M1 - e00741

ER -